ArticleJournal of neuroscience methods2009
A novel apparatus for lateral fluid percussion injury in the rat.
Article in Journal of neuroscience methods, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Epilepsy Characteristics in Neurodevelopmental Disorders: Research from Patient Cohorts and Animal Models Focusing on Autism Spectrum Disorder.International journal of molecular sciences · 2022Review
- Pediatric Traumatic Brain Injury: An Update on Preclinical Models, Clinical Biomarkers, and the Implications of Cerebrovascular Dysfunction.Journal of central nervous system disease · 2022Review
- Article
- The neuroprotective effects of pregabalin after cerebral ischemia by occlusion of the middle cerebral artery in rats.Experimental and therapeutic medicine · 2021Article
- Animal Models of Post-Traumatic Epilepsy.Diagnostics (Basel, Switzerland) · 2019Review
- Progressive, Seizure-Like, Spike-Wave Discharges Are Common in Both Injured and Uninjured Sprague-Dawley Rats: Implications for the Fluid Percussion Injury Model of Post-Traumatic Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Blocking leukotriene synthesis attenuates the pathophysiology of traumatic brain injury and associated cognitive deficits.Experimental neurology · 2014Article
- Reversal of established traumatic brain injury-induced, anxiety-like behavior in rats after delayed, post-injury neuroimmune suppression.Journal of neurotrauma · 2014Article
- ADC mapping and T1-weighted signal changes on post-injury MRI predict seizure susceptibility after experimental traumatic brain injury.Neurological research · 2014Article
- GABA(A) receptor regulation after experimental traumatic brain injury.Journal of neurotrauma · 2012Article
- A method for the intracranial delivery of reagents to voltammetric recording sites.Journal of neuroscience methods · 2012Article
- Acute neuroimmune modulation attenuates the development of anxiety-like freezing behavior in an animal model of traumatic brain injury.Journal of neurotrauma · 2012Article
- MALDI mass spectrometric imaging of lipids in rat brain injury models.Journal of the American Society for Mass Spectrometry · 2011Article
- Key role of sulfonylurea receptor 1 in progressive secondary hemorrhage after brain contusion.Journal of neurotrauma · 2009Article
- Novel model of frontal impact closed head injury in the rat.Journal of neurotrauma · 2009Article
- Injury-related production of cysteinyl leukotrienes contributes to brain damage following experimental traumatic brain injury.Journal of neurotrauma · 2009Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Lateral fluid percussion injury (LFPI) is the most commonly used experimental model of human traumatic brain injury (TBI). To date, investigators using this model have produced injury using a pendulum-and-piston-based device (PPBD) to drive fluid against an intact dural surface. Two disadvantages of this method, however, are (1) the necessary reliance on operator skill to position and release the pendulum, and (2) reductions in reproducibility due to variable friction between the piston's o-rings and the cylinder. To counteract these disadvantages, we designed a low-priced, novel, fluid percussion apparatus that delivers a pressure pulse of air to a standing column of fluid, forcing it against the intact dural surface. The pressure waveforms generated by this apparatus are similar to those reported in the LFPI/PPBD literature and had little variation in appearance between trials. In addition, our apparatus produced an acute and chronic TBI syndrome similar to that in the LFPI/PPBD literature, as quantified by histological changes, MRI structural changes and chronic behavioral sequelae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.