ArticleDevelopmental biology2009
Larval leg integrity is maintained by Distal-less and is required for proper timing of metamorphosis in the flour beetle, Tribolium castaneum.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- Review
- UTR-specific knockdown of Distal-less and Sp8 leads to new phenotypic variants in the flour beetle Tribolium.Development genes and evolution · 2018Article
- Evolution and multiple roles of the Pancrustacea specific transcription factor zelda in insects.PLoS genetics · 2017Article
- The POU factor ventral veins lacking/Drifter directs the timing of metamorphosis through ecdysteroid and juvenile hormone signaling.PLoS genetics · 2014Article
- Article
- Odoriferous Defensive stink gland transcriptome to identify novel genes necessary for quinone synthesis in the red flour beetle, Tribolium castaneum.PLoS genetics · 2013Article
- Extent With Modification: Leg Patterning in the Beetle Tribolium castaneum and the Evolution of Serial Homologs.G3 (Bethesda, Md.) · 2012Article
- Patterning of the adult mandibulate mouthparts in the red flour beetle, Tribolium castaneum.Genetics · 2012Article
- Evolution of nubbin function in hemimetabolous and holometabolous insect appendages.Developmental biology · 2011Article
- Development of an RNA interference method in the cladoceran crustacean Daphnia magna.Development genes and evolution · 2011Article
- Functionality of the GAL4/UAS system in Tribolium requires the use of endogenous core promoters.BMC developmental biology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The dramatic transformation from a larva to an adult must be accompanied by a coordinated activity of genes and hormones that enable an orchestrated transformation from larval to pupal/adult tissues. The maintenance of larval appendages and their subsequent transformation to appendages in holometabolous insects remains elusive at the developmental genetic level. Here the role of a key appendage patterning gene Distal-less (Dll) was examined in mid- to late-larval stages of the flour beetle, Tribolium castaneum. During late larval development, Dll was expressed in appendages in a similar manner as previously reported for the tobacco hornworm, Manduca sexta. Removal of this late Dll expression resulted in disruption of adult appendage patterning. Intriguingly, earlier removal resulted in dramatic loss of structural integrity and identity of larval appendages. A large amount of variability in appendage morphology was observed following Dll dsRNA injection, unlike larvae injected with dachshund dsRNA. These Dll dsRNA-injected larvae underwent numerous supernumerary molts, which could be terminated with injection of either JH methyltransferase or Methoprene-tolerant dsRNA. Apparently, the partial dedifferentiation of the appendages in these larvae acts to maintain high JH and, hence, prevents metamorphosis.
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