ArticleEvolution & development
Abundant genetic variation in transcript level during early Drosophila development.
Article in Evolution & development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Genetic, Environmental, and Stochastic Components of Lifespan Variability: TheInternational journal of molecular sciences · 2024Review
- Evolution and Developmental System Drift in the Endoderm Gene Regulatory Network ofFrontiers in cell and developmental biology · 2020Review
- Inference of Transcription Factor Regulation Patterns Using Gene Expression Covariation in Natural Populations ofBiophysics · 2018Article
- Genomic Characterization of the Evolutionary Potential of the Sea Urchin Strongylocentrotus droebachiensis Facing Ocean Acidification.Genome biology and evolution · 2016Article
- The impact of gene expression variation on the robustness and evolvability of a developmental gene regulatory network.PLoS biology · 2013Article
- Dissecting sources of quantitative gene expression pattern divergence between Drosophila species.Molecular systems biology · 2012Article
- A model-based method for gene dependency measurement.PloS one · 2012Article
- Article
- The strength of transcription-factor binding modulates co-variation in transcriptional networks.Trends in genetics : TIG · 2010Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Variation in gene expression may underlie many important evolutionary traits. However, it is not known at what stage in organismal development changes in gene expression are most likely to result in changes in phenotype. One widely held belief is that changes in early development are more likely to result in changes in downstream phenotypes. In order to discover how much genetic variation for transcript level is present in natural populations, we studied zygotic gene expression in nine inbred lines of Drosophila melanogaster at two time points in their development. We find abundant variation for transcript level both between lines and over time; close to half of all expressed genes show a significant line effect at either time point. We examine the contribution of maternally loaded genes to this variation, as well as the contribution of variation in upstream genes to variation in their downstream targets in two well-studied gene regulatory networks. Finally, we estimate the dimensionality of gene expression in these two networks and find that-despite large numbers of varying genes-there appear to be only two factors controlling this variation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.