ArticleJournal of neuroscience research2009
Cortactin colocalizes with filopodial actin and accumulates at IgCAM adhesion sites in Aplysia growth cones.
Article in Journal of neuroscience research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Neuronal NADPH oxidase is required for neurite regeneration of Aplysia bag cell neurons.Journal of neurochemistry · 2023Article
- A Co-purification Method for Efficient Production and Src Kinase-mediated Phosphorylation ofBio-protocol · 2021Article
- A single tyrosine phosphorylation site in cortactin is important for filopodia formation in neuronal growth cones.Molecular biology of the cell · 2019Article
- Reciprocal Interactions between Cell Adhesion Molecules of the Immunoglobulin Superfamily and the Cytoskeleton in Neurons.Frontiers in cell and developmental biology · 2016Review
- Substrate Deformation Predicts Neuronal Growth Cone Advance.Biophysical journal · 2015Article
- Src and cortactin promote lamellipodia protrusion and filopodia formation and stability in growth cones.Molecular biology of the cell · 2015Article
- Shootin1-cortactin interaction mediates signal-force transduction for axon outgrowth.The Journal of cell biology · 2015Article
- Regulation of ECM degradation and axon guidance by growth cone invadosomes.Development (Cambridge, England) · 2015Article
- Microtechnologies for studying the role of mechanics in axon growth and guidance.Frontiers in cellular neuroscience · 2015Review
- Actin dynamics in growth cone motility and navigation.Journal of neurochemistry · 2014Review
- A cellular model of amyloid precursor protein processing and amyloid-β peptide production.Journal of neuroscience methods · 2014Article
- Growth cone morphology and spreading are regulated by a dynamin-cortactin complex at point contacts in hippocampal neurons.Journal of neurochemistry · 2011Article
- Proteins that promote filopodia stability, but not number, lead to more axonal-dendritic contacts.PloS one · 2011Article
- Identification of genes differentially expressed in dorsal and ventral chick midbrain during early development.BMC developmental biology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Both IgCAMs and the actin cytoskeleton play critical roles in neuronal growth cone motility and guidance. However, it is unclear how IgCAM receptors transduce signals from the plasma membrane to induce actin remodeling. Previous studies have shown that local clustering and immobilization of apCAM, the Aplysia homolog of NCAM, induces Src kinase activity and F-actin polymerization in the peripheral domain of cultured Aplysia bag cell growth cones. Therefore, we wanted to test whether the Src kinase substrate and actin regulator cortactin could be a molecular link between Src activity and actin assembly during apCAM-mediated growth cone guidance. Here, we cloned Aplysia cortactin and showed that it is abundant in the nervous system. Immunostaining of growth cones revealed a strong colocalization of cortactin with F-actin in filopodial bundles and at the leading edge of lamellipodia. Perturbation of the cytoskeleton indicated that cortactin distribution largely depends on actin filaments. Furthermore, active Src colocalized with cortactin in regions of actin assembly, including leading edge and filopodia tips. Finally, we observed that cortactin, like F-actin, localizes to apCAM adhesion sites mediating growth cone guidance. Altogether, these data suggest that cortactin is a mediator of IgCAM-triggered actin assembly involved in growth cone motility and guidance.
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