ReviewFish physiology and biochemistry2009
The effects of heavy metals on embryonic development of fish (a review).
Review in Fish physiology and biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it, 473 citations in OpenAlex.
- Modification Strategies of Kapok Fiber Composites and Its Application in the Adsorption of Heavy Metal Ions and Dyes from Aqueous Solutions: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Comparison of neurobehavioral effects of methylmercury exposure in older and younger adult zebrafish (Danio rerio).Neurotoxicology · 2012Trial
- Neonicotinoid insecticide thiamethoxam compromises early larval development of the Amazonian tetra fish Astyanax bimaculatus (Linnaeus, 1758).Ecotoxicology (London, England) · 2026Article
- Pharmacokinetics and bio-distribution of differently functionalized Carbon nanotube in Zebrafish, Danio rerio.Discover nano · 2026Article
- Developmental Toxicity and Thyroid-Disrupting Effects of Combined Exposure to Pb(II) andToxics · 2026Article
- Assessment of zirconium oxychloride-induced toxicity in Oreochromis niloticus (Linnaeus 1758): from morphological alteration to oxidative stress evaluation.Fish physiology and biochemistry · 2026Article
- Comprehensive profiling of metal compound toxicity: potential novel targets and mechanistic insights using Tox21 screening.Journal of hazardous materials advances · 2026Article
- Lipidomic and neurobehavioral alterations from developmental lead exposure in zebrafish.Journal of hazardous materials · 2026Article
- Risks Associated with Dietary Exposure to Contaminants from Foods Obtained from Marine and Fresh Water, Including Aquaculture.International journal of environmental research and public health · 2026Review
- Xenobiotic exposure may confound traditional stress biomarkers: evaluating perfluoropentanoic acid and cadmium effects on largemouth bass (Conservation physiology · 2026Article
- Physiological and Transcriptome Analyses Offer Insights into Revealing the Mechanisms of Red Tilapia (Antioxidants (Basel, Switzerland) · 2025Article
- Ecotoxicity of Fire Retardants to Zebrafish (Journal of xenobiotics · 2025Article
- Cryopreserved sperm does not affect larval ontogeny and quality in Rhamdia quelen.Fish physiology and biochemistry · 2025Article
- Di-n-butyl and di-iso-pentyl phthalates and their mixture increase oxidative stress and embryo-larval malformations in zebrafish (Danio rerio).Genetics and molecular biology · 2025Article
- Comparative Aquatic Risk of Three Glyphosate-Based Herbicides Using Early-Stage Development ofJournal of toxicology · 2025Article
- Analysis of Differential Gene Expression under Acute Lead or Mercury Exposure in Larval Zebrafish Using RNA-Seq.Animals : an open access journal from MDPI · 2024Article
- Effect of Pb, Cu and Zn on development and Wnt/β-catenin signaling pathway genes expression ofToxicology research · 2024Article
- Shedding Light on Heavy Metal Contamination: Fluorescein-Based Chemosensor for Selective Detection of HgInternational journal of molecular sciences · 2024Article
- Hexavalent Chromium Inhibited Zebrafish Embryo Development by Altering Apoptosis- and Antioxidant-Related Genes.Current issues in molecular biology · 2023Article
- Alterations to unionid transformation during agricultural and urban contaminants of emerging concern exposures.Ecotoxicology (London, England) · 2023Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early developmental stages of fish are particularly sensitive to water pollution. Heavy metals may affect various developmental processes during the embryonic period, which results in a reduction of offspring quantity and quality. Waterborne metals may accumulate in the gonads of spawners and adversely affect gamete production and viability, or exert direct toxic influence upon developing embryos. The egg shell does not fully protect the embryo against metal penetration, particularly during the swelling phase; thus, metals may accumulate in the egg. The results depend on metal concentration and range from developmental disturbances to death of the embryo. Metals disturb various processes of fish embryonic development and affect the development rate. Early stages just after fertilization are particularly sensitive to metal intoxication, when most disturbances and the highest embryonic mortality occur. Waterborne metals also promote developmental anomalies during organogenesis, including body malformations. Heavy metals often induce a delay in the hatching process, premature hatching, deformations and death of newly hatched larvae. All these disturbances result in reduced numbers and poor quality of the larvae, which show small body size, high frequency of malformations and reduced viability.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.