ArticleJournal of clinical immunology2009
Serine protease activity of Cur l 1 from Curvularia lunata augments Th2 response in mice.
Article in Journal of clinical immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Airborne indoor allergen serine proteases and their contribution to sensitisation and activation of innate immunity in allergic airway disease.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Review
- Airway Mycosis and the Regulation of Type 2 Immunity.Journal of fungi (Basel, Switzerland) · 2020Review
- Selective cleavage of fibrinogen by diverse proteinases initiates innate allergic and antifungal immunity through CD11b.The Journal of biological chemistry · 2019Article
- Cockroach protease allergen induces allergic airway inflammation via epithelial cell activation.Scientific reports · 2017Article
- Vacuolar Serine Protease Is a Major Allergen of Fusarium proliferatum and an IgE-Cross Reactive Pan-Fungal Allergen.Allergy, asthma & immunology research · 2016Article
- Article
- Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway disease.PloS one · 2012Article
- Protease-activated receptor 2 activation of myeloid dendritic cells regulates allergic airway inflammation.Respiratory research · 2011Article
- The protease allergen Pen c 13 induces allergic airway inflammation and changes in epithelial barrier integrity and function in a murine model.The Journal of biological chemistry · 2011Article
- Fungal proteases and their pathophysiological effects.Mycopathologia · 2011Review
- Mucosal sensitization to German cockroach involves protease-activated receptor-2.Respiratory research · 2010Article
- New insights into innate immune mechanisms underlying allergenicity.Mucosal immunology · 2010Review
- German cockroach frass proteases modulate the innate immune response via activation of protease-activated receptor-2.Journal of innate immunity · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleStudies with mite allergens demonstrated that proteolytic activity augments allergic airway inflammation. This knowledge is limited to few enzyme allergens.
objectiveThe objective of this study is to investigate the effect of serine protease Cur l 1 from Curvularia lunata in airway inflammation/hyper-responsiveness.
methodsCur l 1 was purified and inactivated using a serine protease inhibitor. Balb/c mice were sensitized with enzymatically active Cur l 1 or C. lunata extract. Sensitized mice were given booster dose on day 14 with active or inactivated Cur l 1. Intranasal challenge was given on day 28, 29, and 30. Airway hyper-responsiveness was measured by plethysmography. Blood, bronchoalveolar lavage fluid (BALF), spleen, and lungs from mice were analyzed for cellular infiltration, immunoglobulins, and cytokine levels.
resultsMice challenged with enzymatically active Cur l 1 demonstrated significantly higher airway inflammation than inactive Cur l 1 group mice (p < 0.01). There was a significant difference in serum IgE and IgG1 levels among mice immunized with active Cur l 1 and inactive Cur l 1 (p < 0.01). IL-4 and IL-5 were higher in BALF and splenocyte culture supernatant of active Cur l 1 than inactive Cur l 1 mice. Lung histology revealed increased eosinophil infiltration, goblet cell hyperplasia and mucus secretion in active group.
conclusionProteolytic activity of Cur l 1 plays an important role in airway inflammation and the inactivated Cur l 1 has potential to be explored for immunotherapy.
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