ArticleJournal of materials science. Materials in medicine2009
Novel self-assembled amphiphilic poly(epsilon-caprolactone)-grafted-poly(vinyl alcohol) nanoparticles: hydrophobic and hydrophilic drugs carrier nanoparticles.
Article in Journal of materials science. Materials in medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Environmentally Friendly Strategies for Formulating Vegetable Oil-Based Nanoparticles for Anticancer Medicine.Pharmaceutics · 2023Review
- Effect of Lipophilic Chains on the Antitumor Effect of a Dendritic Nano Drug Delivery System.Molecules (Basel, Switzerland) · 2022Article
- Evaluation of the Hemocompatibility and Anticancer Potential of Poly(Pharmaceutics · 2021Article
- Starch/PCL composite nanofibers by co-axial electrospinning technique for biomedical applications.Biomedical engineering online · 2017Article
- SLM produced porous titanium implant improvements for enhanced vascularization and osteoblast seeding.International journal of molecular sciences · 2015Article
- Paclitaxel Nano-Delivery Systems: A Comprehensive Review.Journal of nanomedicine & nanotechnology · 2013Article
- Self-assembled polymeric nanoparticles based on oleic acid-grafted chitosan oligosaccharide: biocompatibility, protein adsorption and cellular uptake.Journal of materials science. Materials in medicine · 2012Article
- Preparation and characterization of self-assembled nanoparticles based on folic acid modified carboxymethyl chitosan.Journal of materials science. Materials in medicine · 2011Article
- Synthesis of multi-walled carbon nanotube/polyhedral oligomeric silsesquioxane nanohybrid by utilizing click chemistry.Nanoscale research letters · 2011Article
- Formulation of a novel oxybenzone-loaded nanostructured lipid carriers (NLCs).AAPS PharmSciTech · 2010Article
- Development of transferrin functionalized poly(ethylene glycol)/poly(lactic acid) amphiphilic block copolymeric micelles as a potential delivery system targeting brain glioma.Journal of materials science. Materials in medicine · 2010Article
- Electrospun titanium dioxide nanofibers containing hydroxyapatite and silver nanoparticles as future implant materials.Journal of materials science. Materials in medicine · 2010Article
- Preparation and characterization of amphiphilic poly-N-vinylpyrrolidone nanoparticles containing indomethacin.Journal of materials science. Materials in medicine · 2010Article
- In vitro evaluation of folic acid modified carboxymethyl chitosan nanoparticles loaded with doxorubicin for targeted delivery.Journal of materials science. Materials in medicine · 2010Article
- pH- and temperature-sensitive polymeric microspheres for drug delivery: the dissolution of copolymers modulates drug release.Journal of materials science. Materials in medicine · 2009Article
- Surface-modified cobalt oxide nanoparticles: new opportunities for anti-cancer drug development.Cancer nanotechnologyArticle
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In the present study, we have aimed to produce nanoparticles (NPs) possessing the capability of carrying both of the hydrophobic and hydrophilic drugs and reveal significant release for both drug types. Poly(epsilon-caprolactone) (PCL) grafted poly(vinyl alcohol) (PVA) copolymer (PCL-g-PVA) has been prepared and shaped in nano-particulate form to be adequate for carrying the drugs. Stannous octoate (Sn(II)Oct(2)) was used to catalyze PVA and epsilon-caprolactone monomer to chemically bond. Moreover, this catalyst enhanced side chain polymerization reaction for the utilized epsilon-caprolactone monomer to form poly(epsilon-caprolactone) (PCL). The formed PCL was attached as branches with PVA backbone. (1)H NMR has confirmed formation of PCL and grafting of PVA by this new polymer. Moreover, the vibration modes in the functional groups of PCL-g-PVA have been detected by FT-IR. The thermal alteration in the grafted polymer was checked by TGA analysis. The successfully synthesized grafted copolymer was able to self-aggregate into NPs by direct dialysis method. The size, morphology and charges associated with the obtained NPs were analyzed by DLS, TEM and ELS, respectively. PCL-g-PVA NPs were investigated as drug carrier models for hydrophobic and hydrophilic anti cancer drugs; paclitaxel and doxorubicin. In vitro drug release experiments were conducted; the loaded NPs reveal continuous and sustained release form for both drugs, up to 20 and 15 days for paclitaxel and doxorubicin, respectively. However, in a case of using pure drugs only, both drugs completely released within 1-2 h. The overall obtained results strongly recommend the use these novel NPs in future drug delivery systems.
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