ArticleHuman genetics2009
The joint association between F5 gene polymorphisms and maternal smoking during pregnancy on preterm delivery.
Article in Human genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- The Role of Genetics in Preterm Birth.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Boston Birth Cohort profile: rationale and study design.Precision nutrition · 2022Article
- Association of Residence in High-Police Contact Neighborhoods With Preterm Birth Among Black and White Individuals in Minneapolis.JAMA network open · 2021Article
- Spontaneous preterm birth: advances toward the discovery of genetic predisposition.American journal of obstetrics and gynecology · 2018Review
- Differential effects of stress and African ancestry on preterm birth and related traits among US born and immigrant Black mothers.Medicine · 2017Observational
- Spontaneous preterm birth and single nucleotide gene polymorphisms: a recent update.BMC genomics · 2016Review
- Bridging the gaps between the histopathological and demographic risk factors of preterm birth in a unique Miami inner-city population.Fetal and pediatric pathology · 2014Article
- Targeted next-generation resequencing of f5 gene identifies novel multiple variants pattern in severe hereditary factor v deficiency.Case reports in genetics · 2013Article
- California Very Preterm Birth Study: design and characteristics of the population- and biospecimen bank-based nested case-control study.Paediatric and perinatal epidemiology · 2012Article
- Associations between gene polymorphisms in fatty acid metabolism pathway and preterm delivery in a US urban black population.Human genetics · 2012Article
- Role of African ancestry and gene-environment interactions in predicting preterm birth.Obstetrics and gynecology · 2011Article
- Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.American journal of obstetrics and gynecology · 2010Article
- Global report on preterm birth and stillbirth (2 of 7): discovery science.BMC pregnancy and childbirth · 2010Article
- Developmental origins of health and disease: environmental exposures.Seminars in reproductive medicine · 2009Review
- Early life environment and developmental immunotoxicity in inflammatory dysfunction and disease.Toxicological and environmental chemistryArticle
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Factor V (F5) genetic variants and maternal smoking during pregnancy individually has been associated with increased risk of preterm delivery (PTD). We hypothesize that F5 gene and maternal smoking may synergistically increase the risk of PTD. Three single nucleotide polymorphisms (SNPs) in F5 gene (rs6019, rs2213869 and rs6022) were genotyped in 542 mothers with PTD and 1,141 mothers with term deliveries at the Boston Medical Center. The individual and interactive effects of F5 SNPs and maternal smoking on PTD and gestational age were examined, respectively. The results suggested that maternal smoking, three F5 SNPs and F5 haplotype were individually associated with PTD and gestational age. More importantly, we found significant interactions between the two F5 SNPs (rs6019 and rs6022) and maternal smoking on PTD and gestational age. Compared with non-smoking mothers carrying rs6019 GG genotype, persistently smoking mothers carrying genotypes GC or CC were associated with significantly increased risk of PTD (OR(95% CI): 2.1(1.2-3.6) for GC; 5.7(2.1-15.0) for CC; p-interaction = 0.02). A significant interaction was also observed for gestational age. Similar pattern of interactions was found between rs6022 and maternal smoking on PTD. In summary, our data indicated that F5 gene variants and maternal smoking may synergistically increase the risk of PTD.
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