ArticleEuropean archives of psychiatry and clinical neuroscience2008
Isn't the efficacy of antidepressants clinically relevant? A critical comment on the results of the metaanalysis by Kirsch et al. 2008.
Article in European archives of psychiatry and clinical neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Guidelines for the pharmacological acute treatment of major depression: conflicts with current evidence as demonstrated with the German S3-guidelines.BMC psychiatry · 2019Pooled it
- The efficacy of paroxetine and placebo in treating anxiety and depression: a meta-analysis of change on the Hamilton Rating Scales.PloS one · 2014Pooled it
- Antidepressive Effectiveness of Amisulpride, Aripiprazole, and Olanzapine in Patients With Schizophrenia Spectrum Disorders: A Secondary Outcome Analysis of a Pragmatic, Randomized Trial (BeSt InTro).Journal of clinical psychopharmacologyTrial
- EPA guidance on improving the image of psychiatry.European archives of psychiatry and clinical neuroscience · 2016Article
- The public debate on psychotropic medication and changes in attitudes 1990-2011.European archives of psychiatry and clinical neuroscience · 2016Article
- How close is evidence to truth in evidence-based treatment of mental disorders?European archives of psychiatry and clinical neuroscience · 2012Article
- Executive summary of the report by the WPA section on pharmacopsychiatry on general and comparative efficacy and effectiveness of antidepressants in the acute treatment of depressive disorders.European archives of psychiatry and clinical neuroscience · 2012Article
- General and comparative efficacy and effectiveness of antidepressants in the acute treatment of depressive disorders: a report by the WPA section of pharmacopsychiatry.European archives of psychiatry and clinical neuroscience · 2011Article
- Achievement and maintenance of the new impact factor 2010.European archives of psychiatry and clinical neuroscience · 2011Article
- Electroconvulsive treatment of a patient with Parkinson's disease and moderate depression.Mental illness · 2011Review
- Effectiveness studies: advantages and disadvantages.Dialogues in clinical neuroscience · 2011Review
- [Efficiency of antidepressant therapy for patients with less severe depression].Der Internist · 2010Article
- Antidepressant-induced suicidality: an update.CNS neuroscience & therapeutics · 2010Review
- Evidence-based medicine in psychopharmacotherapy: possibilities, problems and limitations.European archives of psychiatry and clinical neuroscience · 2010Article
- Meta-analyses: a method to maximise the evidence from clinical studies?European archives of psychiatry and clinical neuroscience · 2010Article
- Principle standards and problems regarding proof of efficacy in clinical psychopharmacology.European archives of psychiatry and clinical neuroscience · 2010Article
- [Core symptoms of depression].Der Nervenarzt · 2009Article
- [Unipolar depressive disorders].Der Nervenarzt · 2009Article
- [Core symptoms of depression. Effectiveness of antidepressant therapy].Der Nervenarzt · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The metaanalysis of Kirsch (PLoS Med 5:e45, 2008) has (unfortunately!) attracted too much attention in the specialized press and especially in the lay press. Therefore, intensive critical commenting is necessary to not further alarm experts and health authorities as well as patients and family members. The specified commenting on these metaanalyses shall be prefaced with a short and critical commentary regarding the general significance of metaanalyses. The results of metaanalyses should not too naively be interpreted as the 'truth' as regards to the evidence based psychopharmacotherapy, but should be qualified in their significance due to principal methodological reasons Maier (Nervenarzt 78:1028-1036, 2007; Möller (Nervenarzt 78:1014-1027, 2007). Especially from these derived effect sizes should be interpreted carefully.
Indexed as
Identifiers
19020794What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.