ArticlePloS one2008
ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytes.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Cross-sectional and longitudinal associations of apolipoprotein A1 and B with glycosylated hemoglobin in Chinese adults.Scientific reports · 2022Trial
- Associations of apolipoprotein A1, apolipoprotein B, and their ratio with novel cardiometabolic indices in adults with coronary artery disease.Frontiers in cardiovascular medicine · 2026Article
- Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis.Circulation research · 2024Article
- ApoB100 and Atherosclerosis: What's New in the 21st Century?Metabolites · 2024Review
- The Correlation of Apolipoprotein B with Alterations in Specific Fat Depots Content in Adults.International journal of molecular sciences · 2023Article
- Weight trajectories since birth, current body composition and metabolic traits in young, normal-weight Japanese women with high percentage body fat.BMJ open diabetes research & care · 2022Article
- Association of apolipoproteins A1 and B with type 2 diabetes and fasting blood glucose: a cross-sectional study.BMC endocrine disorders · 2021Article
- Low Carbohydrate Dietary Approaches for People With Type 2 Diabetes-A Narrative Review.Frontiers in nutrition · 2021Review
- Lipid Complications after Hematopoietic Stem Cell Transplantation (HSCT) in Pediatric Patients.Nutrients · 2020Article
- Cholesterol-Lowering Gene Therapy Prevents Heart Failure with Preserved Ejection Fraction in Obese Type 2 Diabetic Mice.International journal of molecular sciences · 2019Article
- Differential expression and accumulation of 14-3-3 paralogs in 3T3-L1 preadipocytes and differentiated cells.Biochemistry and biophysics reports · 2016Article
- An apolipoprotein B100 mimotope prevents obesity in mice.Clinical science (London, England : 1979) · 2016Article
- Low density lipoprotein delays clearance of triglyceride-rich lipoprotein by human subcutaneous adipose tissue.Journal of lipid research · 2013Article
- TSC22D4 is a molecular output of hepatic wasting metabolism.EMBO molecular medicine · 2013Article
- Adipocyte triglyceride turnover is independently associated with atherogenic dyslipidemia.Journal of the American Heart Association · 2012Article
- β(2)-Adrenoceptors increase translocation of GLUT4 via GPCR kinase sites in the receptor C-terminal tail.British journal of pharmacology · 2012Article
- HBV inhibits apoB production via the suppression of MTP expression.Lipids in health and disease · 2011Article
- Is the metabolic syndrome caused by a high fructose, and relatively low fat, low cholesterol diet?Archives of medical science : AMS · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFree fatty acids released from adipose tissue affect the synthesis of apolipoprotein B-containing lipoproteins and glucose metabolism in the liver. Whether there also exists a reciprocal metabolic arm affecting energy metabolism in white adipose tissue is unknown. METHODS AND
findingsWe investigated the effects of apoB-containing lipoproteins on catecholamine-induced lipolysis in adipocytes from subcutaneous fat cells of obese but otherwise healthy men, fat pads from mice with plasma lipoproteins containing high or intermediate levels of apoB100 or no apoB100, primary cultured adipocytes, and 3T3-L1 cells. In subcutaneous fat cells, the rate of lipolysis was inversely related to plasma apoB levels. In human primary adipocytes, LDL inhibited lipolysis in a concentration-dependent fashion. In contrast, VLDL had no effect. Lipolysis was increased in fat pads from mice lacking plasma apoB100, reduced in apoB100-only mice, and intermediate in wild-type mice. Mice lacking apoB100 also had higher oxygen consumption and lipid oxidation. In 3T3-L1 cells, apoB100-containing lipoproteins inhibited lipolysis in a dose-dependent fashion, but lipoproteins containing apoB48 had no effect. ApoB100-LDL mediated inhibition of lipolysis was abolished in fat pads of mice deficient in the LDL receptor (Ldlr(-/-)Apob(100/100)).
conclusionsOur results show that the binding of apoB100-LDL to adipocytes via the LDL receptor inhibits intracellular noradrenaline-induced lipolysis in adipocytes. Thus, apoB100-LDL is a novel signaling molecule from the liver to peripheral fat deposits that may be an important link between atherogenic dyslipidemias and facets of the metabolic syndrome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.