ArticleJournal of perinatology : official journal of the California Perinatal Association2009
Splanchnic tissue oxygenation, but not brain tissue oxygenation, increases after feeds in stable preterm neonates tolerating full bolus orogastric feeding.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Enterocolitis
Evaluation of Abdominal Tissue Oxygenation in Premature Infants Using Near Infrared Spectroscopy
Evaluation of Feeding Intolerance in Premature Infants Using Near Infrared Spectroscopy
Who cites it
33 citing papers in PubMed, 80 citations in OpenAlex.
- A prospective study describing splanchnic NIRS and clinical outcomes in encephalopathic neonates receiving minimal enteral nutrition during therapeutic hypothermia.Journal of perinatology : official journal of the California Perinatal Association · 2025Trial
- The effects of nutrition on mesenteric oxygenation among neonates with neonatal encephalopathy: a randomized clinical trial.Pediatric research · 2025Trial
- The effect of drip versus intermittent feeding on splanchnic oxygenation in preterm infants with intrauterine growth restriction: a prospective randomized trial.European journal of pediatrics · 2023Trial
- Electrogastrography, Near-infrared Spectroscopy, and Acoustics to Measure Gastrointestinal Development in Preterm Babies.Journal of pediatric gastroenterology and nutrition · 2018Trial
- Variability in splanchnic tissue oxygenation during preterm red blood cell transfusion given for symptomatic anaemia may reveal a potential mechanism of transfusion-related acute gut injury.Blood transfusion = Trasfusione del sangue · 2015Trial
- Trial
- Nutrition of the preterm infant with persistent ductus arteriosus: existing evidence and practical implications.Pediatric research · 2026Review
- Effect of Slow Versus Rapid Advancement of Enteral Feeding on Intestinal Oxygenation in Preterm Infants.Children (Basel, Switzerland) · 2025Article
- Utility of Abdominal Near Infrared Spectroscopy in the Management of Neonates: A Review.American journal of perinatology · 2025Review
- Nutritional Management for Preterm Infants with Common Comorbidities: A Narrative Review.Nutrients · 2025Review
- Regional tissue oxygen saturation during minimal enteral feeding is associated with the subsequent feeding intolerance in very preterm infants.Scientific reports · 2025Article
- Utilizing mesenteric near-infrared reflectance spectroscopy to predict gastrointestinal complication risks and optimize feeding strategies in infants undergoing cardiac surgery.Pediatric investigation · 2024Article
- Review
- Abdominal Near Infrared Spectroscopy can be reliably used to measure splanchnic oxygenation changes in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Cerebral and splanchnic near-infrared spectroscopic dataset in premature newborns receiving packed red blood cell transfusion.Data in brief · 2023Article
- Feeding intolerance.Early human development · 2022Article
- Regional Splanchnic Oxygenation during Continuous versus Bolus Feeding among Stable Preterm Infants.Children (Basel, Switzerland) · 2022Article
- Regional tissue oxygenation and conventional indicators of red blood cell transfusion in anaemic preterm infants.EClinicalMedicine · 2022Article
- Hierarchical improvement of regional tissue oxygenation after packed red blood cell transfusion.PloS one · 2022Article
- Effects of Pneumoperitoneum on Splanchnic Oxygenation during Abdominal Laparoscopic Surgery in Paediatric Patients: A prospective, Observational Study.Turkish journal of anaesthesiology and reanimation · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this prospective, observational study was to test the hypothesis that tissue oxygenation in the splanchnic bed compared with tissue oxygenation in the cerebral circulation changes after feeding in preterm neonates who are tolerating full bolus orogastric feeds. STUDY
designClinically stable premature neonates with postmenstrual age between 32 and 35(6/7) weeks who were tolerating full bolus feedings were studied before feeding and 1 h after feeding using near-infrared spectroscopy. The ratio of oxygenated to reduced hemoglobin (tissue oxygenation index, TOI) in the splanchnic circulation bed was divided by the TOI in the cerebral circulation, thereby yielding the cerebro-splanchnic oxygenation ratio (CSOR). We compared TOI and CSOR before and after feeding. As the changes in TOI and CSOR had non-Gaussian distribution, nonparametric statistics were used.
resultAmong 32 infants, CSOR increased significantly after feeding (median difference 0.08; range -0.48, +0.58; P=0.011), whereas pulse oximetry did not change significantly (P=0.600). The change in CSOR with feeding was associated with a significant increase in splanchnic TOI (preprandial median 43.8, range 25.2-68.4 vs postprandial 47.5, range 25.8-70.8; P=0.013), without any significant change in brain TOI (preprandial median 64.9, range 44.5-75.4 vs postprandial 58.9, range 42.2-72.3; P=0.153).
conclusionThis study indicates that CSOR and splanchnic TOI, but not brain TOI, increase significantly after feeding in stable preterm infants who are tolerating full orogastric feeds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.