ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Neural analog of arousal: persistent conditional activation of a feeding modulator by serotonergic initiators of locomotion.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- A brain-gut excitatory peptide/CCHamide homolog regulates satiation and motivational state transitions in the Aplysia feeding circuit.The Journal of biological chemistry · 2026Article
- Age-related degradation of behavioral and network features ofFrontiers in aging neuroscience · 2026Article
- Age-related degradation of behavioral and network features ofbioRxiv : the preprint server for biology · 2025Article
- A conserved gastropod withdrawal circuit inJournal of neurophysiology · 2024Article
- Coordination of Locomotion by Serotonergic Neurons in the Predatory GastropodThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Identification of three elevenin receptors and roles of elevenin disulfide bond and residues in receptor activation in Aplysia californica.Scientific reports · 2023Article
- A Single Central Pattern Generator for the Control of a Locomotor Rolling Wave in MolluscResearch (Washington, D.C.) · 2023Article
- A common modular design of nervous systems originating in soft-bodied invertebrates.Frontiers in physiology · 2023Article
- Identification of an allatostatin C signaling system in mollusc Aplysia.Scientific reports · 2022Article
- Command or Obey? Homologous Neurons Differ in Hierarchical Position for the Generation of Homologous Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Peptide Cotransmitters as Dynamic, Intrinsic Modulators of Network Activity.Frontiers in neural circuits · 2018Review
- Article
- A d-Amino Acid-Containing Neuropeptide Discovery Funnel.Analytical chemistry · 2016Article
- Aplysia Locomotion: Network and Behavioral Actions of GdFFD, a D-Amino Acid-Containing Neuropeptide.PloS one · 2016Article
- Effects of serotonin on the heartbeat of pond snails in a hunger state.Biophysics (Nagoya-shi, Japan) · 2015Article
- Aplysia Ganglia preparation for electrophysiological and molecular analyses of single neurons.Journal of visualized experiments : JoVE · 2014Article
- Characterization of GdFFD, a D-amino acid-containing neuropeptide that functions as an extrinsic modulator of the Aplysia feeding circuit.The Journal of biological chemistry · 2013Article
- Latent modulation: a basis for non-disruptive promotion of two incompatible behaviors by a single network state.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Parallel evolution of serotonergic neuromodulation underlies independent evolution of rhythmic motor behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Localization of serotonin in the nervous system of Biomphalaria glabrata, an intermediate host for schistosomiasis.The Journal of comparative neurology · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We investigated how a neural analog of a form of arousal induced by a mildly noxious stimulus can promote two antagonistic responses, locomotion and feeding. Two pairs of cerebral serotonergic interneurons in Aplysia, CC9 and CC10, were persistently activated by transient noxious stimuli. Direct stimulation of CC9-10 activated locomotor activity that outlasted the stimulation and enhanced subsequent nerve-evoked locomotor programs. Thus, CC9-10 function both as initiators and as modulators of the locomotor network. CC9-10 also interacted with the feeding circuit but in a fundamentally different manner. CC9-10 did not directly trigger feeding activity or activate feeding command or pattern generating interneurons. CC9-10 did, however, elicit slow EPSPs in serotonergic cells that modulate feeding responses, the metacerebral cells (MCCs). CC9-10 persistently enhanced MCC excitability, but did not activate the MCCs directly. Previous work has demonstrated that the MCCs are activated during food ingestion via a sensory neuron C2. Interestingly, we found that CC9-10 stimulation converted subthreshold C2 mediated excitation of the MCC into suprathreshold excitation. Transient noxious stimuli also enhanced MCC excitability, and this was largely mediated by CC9-10. To summarize, CC9-10 exert actions on the feeding network, but their functional effects appear to be conditional on the presence of food-related inputs to the MCCs. A potential advantage of this arrangement is that it may prevent conflicting responses from being directly evoked by noxious stimuli while also facilitating the ability of food-related stimuli to generate feeding responses in the aftermath of noxious stimulation.
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