ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Specific glial populations regulate hippocampal morphogenesis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50 citing papers in PubMed, 97 citations in OpenAlex.
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- An early Sox2-dependent gene expression programme required for hippocampal dentate gyrus development.Open biology · 2021Article
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- The Spindle-Associated Microcephaly Protein, WDR62, Is Required for Neurogenesis and Development of the Hippocampus.Frontiers in cell and developmental biology · 2020Article
- Cajal-Retzius neurons are required for the development of the human hippocampal fissure.Journal of anatomy · 2019Article
- Epigenetic modulation during hippocampal development.Biomedical reports · 2018Review
- NFIB Haploinsufficiency Is Associated with Intellectual Disability and Macrocephaly.American journal of human genetics · 2018Article
- Liver X receptor β regulates the development of the dentate gyrus and autistic-like behavior in the mouse.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampus plays an integral role in spatial navigation, learning and memory, and is a major site for adult neurogenesis. Critical to these functions is the proper organization of the hippocampus during development. Radial glia are known to regulate hippocampal formation, but their precise function in this process is yet to be defined. We find that in Nuclear Factor I b (Nfib)-deficient mice, a subpopulation of glia from the ammonic neuroepithelium of the hippocampus fail to develop. This results in severe morphological defects, including a failure of the hippocampal fissure, and subsequently the dentate gyrus, to form. As in wild-type mice, immature nestin-positive glia, which encompass all types of radial glia, populate the hippocampus in Nfib-deficient mice at embryonic day 15. However, these fail to mature into GLAST- and GFAP-positive glia, and the supragranular glial bundle is absent. In contrast, the fimbrial glial bundle forms, but alone is insufficient for proper hippocampal morphogenesis. Dentate granule neurons are present in the mutant hippocampus but their migration is aberrant, likely resulting from the lack of the complete radial glial scaffold usually provided by both glial bundles. These data demonstrate a role for Nfib in hippocampal fissure and dentate gyrus formation, and that distinct glial bundles are critical for correct hippocampal morphogenesis.
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Registered trials
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