ArticleJournal of the American Society of Nephrology : JASN2009
Imatinib suppresses cryoglobulinemia and secondary membranoproliferative glomerulonephritis.
Article in Journal of the American Society of Nephrology : JASN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Predictive Value of Precision-Cut Kidney Slices as an Ex Vivo Screening Platform for Therapeutics in Human Renal Fibrosis.Pharmaceutics · 2020Article
- Dysregulated mesenchymal PDGFR-β drives kidney fibrosis.EMBO molecular medicine · 2020Article
- Imatinib mesylate use in refractory eosinophilic granulomatosis with polyangiitis: a literature review and a case report.Clinical rheumatology · 2018Review
- Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis.Cancer cell · 2018Article
- Targeting CTGF, EGF and PDGF pathways to prevent progression of kidney disease.Nature reviews. Nephrology · 2014Review
- Thymic neoplasm: a rare disease with a complex clinical presentation.Journal of thoracic disease · 2013Article
- Membranous nephropathy, leiomyoma and autoimmune myasthenia: more than a coincidence?Clinical kidney journal · 2012Article
- Nilotinib attenuates renal injury and prolongs survival in chronic kidney disease.Journal of the American Society of Nephrology : JASN · 2011Article
- Management of the kidney transplant patient with chronic hepatitis C infection.International journal of nephrology · 2011Article
- Targeting non-malignant disorders with tyrosine kinase inhibitors.Nature reviews. Drug discovery · 2010Review
- A spleen tyrosine kinase inhibitor reduces the severity of established glomerulonephritis.Journal of the American Society of Nephrology : JASN · 2010Article
- Deletion of activating Fcgamma receptors does not confer protection in murine cryoglobulinemia-associated membranoproliferative glomerulonephritis.The American journal of pathology · 2009Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Imatinib is a receptor tyrosine kinase inhibitor that blocks the activity of c-Abl, c-Kit, and PDGF receptors. We tested the protective effects of imatinib in thymic stromal lymphopoietin transgenic mice, a model of cryoglobulinemia and associated membranoproliferative glomerulonephritis (MPGN), in which some glomerular manifestations likely result from PDGF receptor activation. Surprising, administration of imatinib beginning at weaning suppressed production of cryoglobulin, attenuating both the renal injury and systemic features of cryoglobulinemia. Flow cytometry suggested that inhibition of B cell development in the bone marrow likely caused the reduction in cryoglobulin production. In addition, administration of imatinib to thymic stromal lymphopoietin transgenic mice with established MPGN also diminished cryoglobulin production and reversed the renal and systemic lesions. These data suggest that treatment with imatinib may be a novel therapeutic approach for cryoglobulinemia and MPGN in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.