ArticleDevelopment (Cambridge, England)2009
Brachyury null mutant-induced defects in juvenile ascidian endodermal organs.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 61 citations in OpenAlex.
- A simple inland culture system provides insights into ascidian post-embryonic developmental physiology.Open biology · 2025Article
- Cis-regulatory interfaces reveal the molecular mechanisms underlying the notochord gene regulatory network of Ciona.Nature communications · 2024Article
- Snail Transcriptionally RepressesInternational journal of molecular sciences · 2024Article
- Mesoderm induction and patterning: Insights from neuromesodermal progenitors.Seminars in cell & developmental biology · 2022Review
- Article
- Brachyury controlsDevelopment (Cambridge, England) · 2021Article
- Ciona Brachyury proximal and distal enhancers have different FGF dose-response relationships.PLoS genetics · 2021Article
- Fgf-driven Tbx protein activities directly induceDevelopment (Cambridge, England) · 2020Article
- Tunicate gastrulation.Current topics in developmental biology · 2020Review
- The notochord gene regulatory network in chordate evolution: Conservation and divergence from Ciona to vertebrates.Current topics in developmental biology · 2020Review
- NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis.Developmental biology · 2019Article
- Positioning a multifunctional basic helix-loop-helix transcription factor within the Ciona notochord gene regulatory network.Developmental biology · 2019Article
- Efficient genome editing using CRISPR-Cas-mediated homology directed repair in the ascidian Ciona robusta.Genesis (New York, N.Y. : 2000) · 2018Article
- Functional and evolutionary insights from theDevelopment (Cambridge, England) · 2017Article
- Cas9-mediated excision ofDevelopment (Cambridge, England) · 2017Article
- The chordate ancestor possessed a single copy of theZoological letters · 2017Article
- Insulin-like genes in ascidians: findings in Ciona and hypotheses on the evolutionary origins of the pancreas.Genesis (New York, N.Y. : 2000) · 2015Review
- Cis-regulatory timers for developmental gene expression.PLoS biology · 2013Article
- Functional Brachyury binding sites establish a temporal read-out of gene expression in the Ciona notochord.PLoS biology · 2013Article
- RNA interference in the appendicularian Oikopleura dioica reveals the function of the Brachyury gene.Development genes and evolution · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We report the isolation of a recessive ENU-induced short-tailed mutant in the ascidian Ciona intestinalis that is the product of a premature stop in the brachyury gene. Notochord differentiation and morphogenesis are severely disrupted in the mutant line. At the larval stage, variable degrees of ectopic endoderm staining were observed in the homozygous mutants, indicating that loss of brachyury results in stochastic fate transformation. In post-metamorphosis mutants, a uniform defect in tail resorption was observed, together with variable defects in digestive tract development. Some cells misdirected from the notochord lineage were found to be incorporated into definitive endodermal structures, such as stomach and intestine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.