ArticleMolecular biology of the cell2009
Dynein-2 affects the regulation of ciliary length but is not required for ciliogenesis in Tetrahymena thermophila.
Article in Molecular biology of the cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Hedgehog pathway, cell cycle, and primary cilium.Cell death discovery · 2025Review
- The retrograde IFT dynein is required for normal function of diverse mechanosensory cilia inFrontiers in molecular neuroscience · 2023Article
- Artificial Intelligence Approaches to Assessing Primary Cilia.Journal of visualized experiments : JoVE · 2021Article
- Establishing and regulating the composition of cilia for signal transduction.Nature reviews. Molecular cell biology · 2019Review
- The role of the dynein light intermediate chain in retrograde IFT and flagellar function in Chlamydomonas.Molecular biology of the cell · 2016Article
- Dynein and intraflagellar transport.Experimental cell research · 2015Review
- FAP206 is a microtubule-docking adapter for ciliary radial spoke 2 and dynein c.Molecular biology of the cell · 2015Article
- Intraflagellar transport gene expression associated with short cilia in smoking and COPD.PloS one · 2014Article
- The snRNA-processing complex, Integrator, is required for ciliogenesis and dynein recruitment to the nuclear envelope via distinct mechanisms.Biology open · 2013Article
- A role for the Golgi matrix protein giantin in ciliogenesis through control of the localization of dynein-2.Journal of cell science · 2013Article
- Primary cilia and kidney injury: current research status and future perspectives.American journal of physiology. Renal physiology · 2013Review
- Stages of ciliogenesis and regulation of ciliary length.Differentiation; research in biological diversity · 2012Review
- Transcriptome analysis of the model protozoan, Tetrahymena thermophila, using Deep RNA sequencing.PloS one · 2012Article
- Article
- A role for Tctex-1 (DYNLT1) in controlling primary cilium length.European journal of cell biology · 2011Article
- Smoking is associated with shortened airway cilia.PloS one · 2009Article
- DYF-1 Is required for assembly of the axoneme in Tetrahymena thermophila.Eukaryotic cell · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eukaryotic cilia and flagella are assembled and maintained by the bidirectional intraflagellar transport (IFT). Studies in alga, nematode, and mouse have shown that the heavy chain (Dyh2) and the light intermediate chain (D2LIC) of the cytoplasmic dynein-2 complex are essential for retrograde intraflagellar transport. In these organisms, disruption of either dynein-2 component results in short cilia/flagella with bulbous tips in which excess IFT particles have accumulated. In Tetrahymena, the expression of the DYH2 and D2LIC genes increases during reciliation, consistent with their roles in IFT. However, the targeted elimination of either DYH2 or D2LIC gene resulted in only a mild phenotype. Both knockout cell lines assembled motile cilia, but the cilia were of more variable lengths and less numerous than wild-type controls. Electron microscopy revealed normally shaped cilia with no swelling and no obvious accumulations of material in the distal ciliary tip. These results demonstrate that dynein-2 contributes to the regulation of ciliary length but is not required for ciliogenesis in Tetrahymena.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.