ArticleJournal of virology2009
Baculovirus data suggest a common but multifaceted pathway for sorting proteins to the inner nuclear membrane.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Identification of the nucleolar localization signal inThe Journal of general virology · 2026Article
- Autographa californica multiple nucleopolyhedrovirusJournal of virology · 2026Article
- Autographa californica multiple nucleopolyhedrovirusJournal of virology · 2024Article
- The XPO6 Exportin Mediates Herpes Simplex Virus 1 gM Nuclear Release Late in Infection.Journal of virology · 2020Article
- Autographa Californica Multiple Nucleopolyhedrovirus P48 (Ac103) Is Required for the Efficient Formation of Virus-Induced Intranuclear Microvesicles.Virologica Sinica · 2019Article
- Baculovirus FP25K Localization: Role of the Coiled-Coil Domain.Journal of virology · 2016Article
- Live imaging and modeling of inner nuclear membrane targeting reveals its molecular requirements in mammalian cells.The Journal of cell biology · 2015Article
- Autographa californica Nucleopolyhedrovirus Ac76: a dimeric type II integral membrane protein that contains an inner nuclear membrane-sorting motif.Journal of virology · 2014Article
- Review
- Characterization of the open reading frame 7a from Bombyx mori nucleopolyhedrovirus.Molecular biology reports · 2013Article
- Effects of Early or Overexpression of the Autographa californica Multiple Nucleopolyhedrovirus orf94 (ODV-e25) on Virus Replication.PloS one · 2013Article
- Comparative proteomics reveal fundamental structural and functional differences between the two progeny phenotypes of a baculovirus.Journal of virology · 2013Article
- Identification and characterization of host factors interacting with Bombyx mori nucleopolyhedrovirus ORF8.Journal of microbiology (Seoul, Korea) · 2012Article
- Autographa californica multiple nucleopolyhedrovirus ac76 is involved in intranuclear microvesicle formation.Journal of virology · 2010Article
- A classical NLS and the SUN domain contribute to the targeting of SUN2 to the inner nuclear membrane.The EMBO journal · 2010Article
- Intranuclear membranes induced by lipidated proteins are derived from the nuclear envelope.Nucleus (Austin, Tex.)Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple unique protein markers sorted to the inner nuclear membrane (INM) from the Autographa californica nucleopolyhedrovirus occlusion-derived virus (ODV) envelope were used to decipher common elements of the sorting pathway of integral membrane proteins from their site of insertion into the membrane of the endoplasmic reticulum (ER) through their transit to the INM. The data show that during viral infection, the viral protein FP25K is a partner for all known ODV envelope proteins and that BV/ODV-E26 (designated E26) is a partner for some, but not all, such proteins. The association with the ER membrane of FP25K, E26, and the cellular INM-sorting protein importin-alpha-16 is not static; rather, these sorting proteins are actively recruited to the ER membrane based upon requirements of the proteins in transit to the INM. Colocalization analysis using an ODV envelope protein and importin-alpha-16 shows that during viral infection, importin-alpha-16 translocates across the pore membrane to the INM and then is incorporated into the virus-induced intranuclear membranes. Thus, the association of importin-alpha-16 and INM-directed proteins appears to remain at least through protein translocation across the pore membrane to the INM. Overall, the data suggest that multiple levels of regulation facilitate INM-directed protein trafficking, and that proteins participating in this sorting pathway have a dynamic relationship with each other and the membrane of the ER.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.