Evidence map›Paper›PMID 19019773›Full record

ArticleAmerican journal of clinical pathology2008

Burkitt lymphoma in Brazil is characterized by geographically distinct clinicopathologic features.

Eduardo M Queiroga, Gabriela Gualco, Lawrence M Weiss, Dirk P Dittmer, Iguaracyra Araujo, Claudette E N Klumb, William J Harrington, Carlos E Bacchi

Abstract read
In one paragraph

Article in American journal of clinical pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Epstein-Barr virus-associated lymphomas.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017
    Review
  15. Article
  16. Article
  17. Burkitt's lymphoma of the jaws in the Amazon region of Brazil.Medicina oral, patologia oral y cirugia bucal · 2014
    Article
  18. Article
  19. Pediatric lymphomas in Brazil.Clinics (Sao Paulo, Brazil) · 2010
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eduardo M QueirogaPathology Reference Laboratory, Botucatu, São Paulo, Brazil.
Gabriela Gualco
Lawrence M Weiss
Dirk P Dittmer
Iguaracyra Araujo
Claudette E N Klumb
William J Harrington
Carlos E Bacchi

Funding

ART Modulation of Viral Pathogenesis in Oral EpitheliaR01DE018304 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DITTMER, DIRK P · 2007 to 2025
$6.9M
Targeted Therapies for HIV-Associated Kaposi Sarcoma and LymphomaR01CA163217 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BLOSSOM A DAMANIA, Dirk P Dittmer · 2011 to 2026
$5.5M
OPTIMIZING HIV/TB MANAGEMENT IN THE HAART ERAD43TW000017 · FIC · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SHOR-POSNER, GAIL · 1988 to 2009
$4.3M
ANTIVIRAL MEDIATED APOPTOSIS OF NON HODGKIN'S LYMPHOMAR01CA082274 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARRINGTON, WILLIAM J · 2000 to 2007
$2.4M
Targeted Therapy for Burkitt Lymphoma in Resource Poor SettingsR01CA121935 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BARBER, GLEN N. · 2006 to 2010
$1.3M
Targeting of EBV Latency in Burkitt's LymphomaR01CA112217 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RAMOS, JUAN CARLOS · 2006 to 2010
$1.2M
FIC NIH HHS D43 TW000017NCI NIH HHS 5R01 CA082274NCI NIH HHS 5R01 CA112217NCI NIH HHS 5R01 CA121935NCI NIH HHS R01 CA082274NCI NIH HHS R01 CA112217NCI NIH HHS R01 CA121935NCI NIH HHS R01 CA163217NIDCR NIH HHS DE018304NIDCR NIH HHS R01 DE018304
6 · The paper itself

Abstract

Burkitt lymphoma (BL) is a highly aggressive non-Hodgkin lymphoma with a consistent MYC translocation. Epstein-Barr virus (EBV) has been associated with BL at different frequencies, depending on the clinical variant and geographic regions. This is a large-scale study of BL in Brazil, including 234 patients from 5 geographic regions that are widely disparate socioeconomically, including pediatric (61.1%) and adult (37.6%) populations. EBV was present in 52.6% of all BL cases, varying from 29% (12/42) in the South to 76% (13/17) in the North. Most of the cases were EBV type A. The frequency was higher in the pediatric group, and EBV association within this age range predominated in all regions except the South. Expression of p53 protein was observed in 16.2%, and only rare cases showed p63 expression. BL in Brazil is regionally distinct and has a low incidence of p53 overexpression and a higher-than-expected association with EBV in sporadic cases.

Indexed as

AdolescentAdultAgedAged, 80 and overBrazilBurkitt LymphomaChildChild, PreschoolFemaleGeographyHerpesvirus 4, HumanHumansImmunohistochemistryInfantIn Situ HybridizationIn Situ Hybridization, FluorescenceTumor Suppressor Protein p53

Identifiers

PMID19019773
PMCPMC2866005

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.