ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2009
Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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5 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Group A Streptococcal meningitis in children: a short case series and systematic review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Pooled it
- Group A Streptococcus strains causing meningitis without distinct invasive phenotype.MicrobiologyOpen · 2024Article
- Group A Streptococcus Infection in Neonatal Population: A Systematic Review of The Literature.Journal of clinical medicine · 2023Review
- A complication of meningitis and infective endocarditis due toBMJ case reports · 2017Article
- [Meningococcal Group A Streptococcus in the newborn: report of a case].The Pan African medical journal · 2015Article
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundOver recent decades, a resurgence of invasive group A streptococcal (GAS) infections has been observed; GAS remains a rare cause of pyogenic meningitis. We report herein population-based findings of long-term surveillance for GAS meningitis in Salvador, Brazil, and estimate the overall burden of invasive GAS infections.
methodsFrom February 1996 to February 2007 we conducted active surveillance for GAS meningitis in the state reference hospital for infectious diseases in Salvador, Brazil. Data on clinical presentation, laboratory records, and outcome were collected through interviews and chart review. GAS isolates were evaluated for antimicrobial susceptibility and emm type.
resultsWe identified 20 cases of GAS meningitis, which accounted for 0.9% of all culture-proven bacterial meningitis in the study period. The mean annual incidence of GAS meningitis was 0.03 cases per 100,000 population in metropolitan Salvador and peaked in children <1 year of age (0.67 cases per 100,000 population). Among 17 cases with clinical information available, 41% required intensive care unit support and 25% died. Tested isolates were susceptible to penicillin and exhibited large emm type diversity. Based on the incidence of GAS meningitis, we estimate that the annual incidence of GAS infection is 3 cases per 100,000 population in metropolitan Salvador.
conclusionsAlthough rare, GAS is a life-threatening cause of bacterial meningitis. Knowledge of the incidence and emm type variability of the disease is necessary for planning immunization strategies.
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