SynthesisJournal of pain and symptom management2009
A review of the prevalence and impact of multiple symptoms in oncology patients.
Synthesis in Journal of pain and symptom management, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
104 citing papers in PubMed, 6 syntheses or guidelines pooled it, 204 citations in OpenAlex.
- Symptom clusters in patients receiving chemotherapy: A systematic review.BMJ supportive & palliative care · 2022Pooled it
- Acupuncture Improves Multiple Treatment-Related Symptoms in Breast Cancer Survivors: A Systematic Review and Meta-Analysis.Journal of alternative and complementary medicine (New York, N.Y.) · 2021Pooled it
- Telephone interventions for symptom management in adults with cancer.The Cochrane database of systematic reviews · 2020Pooled it
- Recommended patient-reported core set of symptoms to measure in adult cancer treatment trials.Journal of the National Cancer Institute · 2014Pooled it
- A literature synthesis of symptom prevalence and severity in persons receiving active cancer treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Pooled it
- Pooled it
- First-time use of electronic patient-reported outcome measures in a cluster randomized trial: a qualitative study.Journal of patient-reported outcomes · 2025Trial
- Improving Symptom Management for Survivors of Young Adult Cancer: Development of a Novel Intervention.Journal of adolescent and young adult oncology · 2023Trial
- Prevalence, Severity, and Co-Occurrence of SPPADE Symptoms in 31,866 Patients With Cancer.Journal of pain and symptom management · 2023Trial
- Network Analysis of the Multidimensional Symptom Experience of Oncology.Scientific reports · 2019Trial
- Repeated measures analyses of dermatitis symptom evolution in breast cancer patients receiving radiotherapy in a phase 3 randomized trial of mometasone furoate vs placebo (N06C4 [alliance]).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Trial
- Randomized controlled pilot study of mindfulness-based stress reduction for persistently fatigued cancer survivors.Psycho-oncology · 2015Trial
- Longitudinal relationships between fatigue and depression in cancer patients with depression and/or pain.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2013Trial
- Somatic symptoms in cancer patients trajectory over 12 months and impact on functional status and disability.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Trial
- Impact of paroxetine on sleep problems in 426 cancer patients receiving chemotherapy: a trial from the University of Rochester Cancer Center Community Clinical Oncology Program.Sleep medicine · 2012Trial
- Association of oral mucositis with quality of life and symptom clusters in patients with solid tumors receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2012Trial
- Article
- Symptoms experienced during the first 4 months of chemotherapy administration: a longitudinal cohort study in an Australian cancer treatment unit.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Patient-Reported Quality of Life Predicts First-Cycle Pharmacotherapy Survival in Breast Cancer: A Prospective Cohort Study.Medical sciences (Basel, Switzerland) · 2026Article
- Electroacupuncture for Managing Chemotherapy-Induced Gastrointestinal Symptom Clusters in Patients With Breast Cancer: Study Protocol for a Randomized Controlled Trial.Health care science · 2026Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Findings from several studies suggest that oncology patients undergoing active treatment experience multiple symptoms, and that these symptoms can have a negative effect on patient outcomes. However, no systematic review has summarized the findings from studies that assessed multiple symptoms in these patients. Therefore, the purposes of this review were to: 1) compare and contrast the characteristics of the three most commonly used instruments to measure multiple symptoms; 2) summarize the prevalence rates for multiple symptoms in studies of oncology patients receiving active treatment; 3) describe the relationships among selected demographic, disease, and treatment characteristics and multiple symptoms; and 4) describe the relationships between the occurrence of multiple symptoms and patient outcomes (i.e., functional status, quality of life). Only 18 studies were found that met the inclusion criteria for this review. The majority of the studies were cross-sectional with sample sizes that ranged from 26 to 527. Approximately 40% of patients experienced more than one symptom. However, little is known about the relationships between demographic and clinical characteristics and the occurrence of multiple symptoms. Findings from this review suggest that the occurrence of multiple symptoms is associated with decreased functional status and quality of life. However, given the large number of oncology patients who undergo active treatment each year, additional research is warranted on the prevalence and impact of multiple symptoms. Only when this descriptive research is completed with homogenous samples of patients in terms of cancer diagnoses and treatments can intervention studies for multiple symptoms be developed and tested.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.