ArticleMolecular and cellular biology1991
Sequence requirements for premature transcription arrest within the first intron of the mouse c-fos gene.
Article in Molecular and cellular biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 83 citations in OpenAlex.
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- Calcium signaling and transcription: elongation, DoGs, and eRNAs.Receptors & clinical investigation · 2016Article
- Bioinformatic analysis reveals an evolutional selection for DNA:RNA hybrid G-quadruplex structures as putative transcription regulatory elements in warm-blooded animals.Nucleic acids research · 2013Article
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- Transcriptional attenuation in colon carcinoma cells in response to butyrate.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- A novel mouse c-fos intronic promoter that responds to CREB and AP-1 is developmentally regulated in vivo.PloS one · 2010Article
- Glucocorticoid resistance in a multiple myeloma cell line is regulated by a transcription elongation block in the glucocorticoid receptor gene (NR3C1).British journal of haematology · 2009Article
- Microarray transfection analysis of conserved genomic sequences from three immediate early genes.Genomics · 2009Article
- Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation.The EMBO journal · 2008Article
- Intracellular monovalent ions as second messengers.The Journal of membrane biology · 2006Review
- Cell-type-specific binding of the transcription factor CREB to the cAMP-response element.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Discovery of regulatory elements by a computational method for phylogenetic footprinting.Genome research · 2002Article
- Molecular events involved in up-regulating human Na+-independent neutral amino acid transporter LAT1 during T-cell activation.The Biochemical journal · 2001Article
- A unique ISRE, in the TATA-less human Isg20 promoter, confers IRF-1-mediated responsiveness to both interferon type I and type II.Nucleic acids research · 2000Article
- Stimulation of the Ca2+-mediated egr-1 and c-fos expression in murine erythroleukaemia cells by cyclosporin A.The Biochemical journal · 1998Article
- Effects of heterologous downstream sequences on the activity of the HIV-1 promoter and its response to Tat.Nucleic acids research · 1997Article
- Purification and characterization of FBI-1, a cellular factor that binds to the human immunodeficiency virus type 1 inducer of short transcripts.Molecular and cellular biology · 1997Article
- Specific combinations of human serum albumin introns direct high level expression of albumin in transfected COS cells and in the milk of transgenic mice.Transgenic research · 1994Article
- Control of transcription arrest in intron 1 of the murine adenosine deaminase gene.Molecular and cellular biology · 1994Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A strong block to the elongation of nascent RNA transcripts by RNA polymerase II occurs in the 5' part of the mammalian c-fos proto-oncogene. In addition to the control of initiation, this mechanism contributes to transcriptional regulation of the gene. In vitro transcription experiments using nuclear extracts and purified transcription templates allowed us to map a unique arrest site within the mouse first intron 385 nucleotides downstream from the promoter. This position is in keeping with that estimated from nuclear run-on assays performed with short DNA probes and thus suggests that it corresponds to the actual block in vivo. Moreover, we have shown that neither the c-fos promoter nor upstream sequences are absolute requirements for an efficient transcription arrest both in vivo and in vitro. Finally, we have characterized a 103-nucleotide-long intron 1 motif comprising the arrest site and sufficient for obtaining the block in a cell-free transcription assay.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.