ArticleMolecular and cellular biology1991
c-fos gene transcription in murine macrophages is modulated by a calcium-dependent block to elongation in intron 1.
Article in Molecular and cellular biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 104 citations in OpenAlex.
- The Promoter-Proximal Pause: A Decision Point Governing RNA Polymerase II Fate.Annual review of biochemistry · 2026Review
- A microfluidic-based approach to investigate the inflammatory response of macrophages to pristine and drug-loaded nanostructured hydroxyapatite.Materials today. Bio · 2022Article
- Emerging themes in neuronal activity-dependent gene expression.Molecular and cellular neurosciences · 2018Review
- Calcium signaling and transcription: elongation, DoGs, and eRNAs.Receptors & clinical investigation · 2016Article
- Article
- Regulation of primary response genes in B cells.The Journal of biological chemistry · 2013Article
- Control of Transcriptional Elongation by RNA Polymerase II: A Retrospective.Genetics research international · 2012Article
- A novel mouse c-fos intronic promoter that responds to CREB and AP-1 is developmentally regulated in vivo.PloS one · 2010Article
- Microarray transfection analysis of conserved genomic sequences from three immediate early genes.Genomics · 2009Article
- Up-regulation of P-TEFb by the MEK1-extracellular signal-regulated kinase signaling pathway contributes to stimulated transcription elongation of immediate early genes in neuroendocrine cells.Molecular and cellular biology · 2008Article
- Identification of Spt5 target genes in zebrafish development reveals its dual activity in vivo.PloS one · 2008Article
- Upregulation of the neuron-specific K+/Cl- cotransporter expression by transcription factor early growth response 4.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Molecular events involved in up-regulating human Na+-independent neutral amino acid transporter LAT1 during T-cell activation.The Biochemical journal · 2001Article
- P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II.Molecular and cellular biology · 2000Review
- Stimulation of the Ca2+-mediated egr-1 and c-fos expression in murine erythroleukaemia cells by cyclosporin A.The Biochemical journal · 1998Article
- Systemic morphine-induced Fos protein in the rat striatum and nucleus accumbens is regulated by mu opioid receptors in the substantia nigra and ventral tegmental area.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Dependence of stimulus-transcription coupling on phospholipase D in agonist-stimulated pituitary cells.Molecular biology of the cell · 1995Article
- Control of transcription arrest in intron 1 of the murine adenosine deaminase gene.Molecular and cellular biology · 1994Article
- Dual modes of control of c-fos mRNA induction by intracellular calcium in T cells.Molecular and cellular biology · 1994Article
- Nuclear Ca2+ concentration measured with specifically targeted recombinant aequorin.The EMBO journal · 1993Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cultured mouse thioglycolate-elicited peritoneal macrophages exhibit a strong block to transcriptional elongation beyond the end of the c-fos gene first exon. This block is absent in freshly isolated peritoneal cells, appears slowly during culture, and does not require adherence of the cells. The extent of this block is largely responsible for the levels of c-fos mRNA in cultured macrophages, even after modulation by agents such as the tumor promoter phorbol myristate acetate and increased intracellular cyclic AMP, which also increase the activity of the c-fos promoter. When macrophages are cultured in the absence of mobilizable calcium, the block can no longer be relieved by any inducing agent. Conversely, upon calcium influxes, there is little alteration in the level of transcriptional initiation, but transcription proceeds efficiently through the entire c-fos locus. These results suggest the presence of an intragenic calcium-responsive element in the c-fos gene and illustrate its key role in the control of c-fos gene transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.