ArticleAmerican journal of obstetrics and gynecology2009
Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.
Article in American journal of obstetrics and gynecology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- What causes racial disparities in very preterm birth? A biosocial perspective.Epidemiologic reviews · 2009Pooled it
- An evolutionary genomic perspective on preterm birth, genome editing, and pregnancy in the human species.Frontiers in genome editing · 2026Review
- Prenatal chronic inflammation and children's executive function development.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2025Article
- Role ofJournal of clinical medicine · 2024Article
- The Role of Genetics in Preterm Birth.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Low-dose aspirin and racial disparities in spontaneous preterm delivery in low-risk individuals.AJOG global reports · 2023Article
- Identifying Candidate Genes for Short Gestation Length Trait in Chinese Qingping Pigs by Whole-Genome Resequencing and RNA Sequencing.Frontiers in genetics · 2022Article
- Racial and ethnic disparities in birth Outcomes: A decomposition analysis of contributing factors.Preventive medicine reports · 2021Article
- Spontaneous preterm birth: the underpinnings in the maternal and fetal genomes.NPJ genomic medicine · 2021Review
- Current Approaches to Risk Assessment and Prevention of Preterm Birth-A Continuing Public Health Crisis.Ochsner journal · 2020Review
- Whole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth.PLoS genetics · 2018Article
- Spontaneous preterm birth: advances toward the discovery of genetic predisposition.American journal of obstetrics and gynecology · 2018Review
- Maternal human telomerase reverse transcriptase variants are associated with preterm labor and preterm premature rupture of membranes.PloS one · 2018Article
- Genome-wide approach identifies a novel gene-maternal pre-pregnancy BMI interaction on preterm birth.Nature communications · 2017Article
- Spontaneous preterm birth and single nucleotide gene polymorphisms: a recent update.BMC genomics · 2016Review
- Racial Differences in DNA-Methylation of CpG Sites Within Preterm-Promoting Genes and Gene Variants.Maternal and child health journal · 2016Article
- The genomics of prematurity in an era of more precise clinical phenotyping: A review.Seminars in fetal & neonatal medicine · 2016Review
- Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study.BMC pregnancy and childbirth · 2016Article
- Article
- Racial differences in risk of spontaneous abortions associated with periconceptional over-the-counter nonsteroidal anti-inflammatory drug exposure.Annals of epidemiology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveThe objective of the study was to study the genetic risk factors of spontaneous preterm birth (PTB) in African Americans. STUDY
designCase-control analyses were performed using maternal and fetal deoxyribonucleic acid from 279 African American birth events (82 PTB and 197 term) and 1432 single-nucleotide polymorphisms from 130 candidate genes. Single-locus association and haplotype analyses were performed.
resultsThe most significant associations were in the maternal interleukin (IL)-15 (rs10833, allele P = 2.91 x 10(-4), genotype P = 2.00 x 10(-3)) gene and the fetal IL-2 receptor B (IL-2RB) (rs84460, allele P = 1.37 x 10(-4), genotype P = 6.29 x 10(-4)) gene. The best models for these markers were additive (rs10833, odds ratio [OR], 0.30; 95% confidence interval [CI], 0.14-0.62; P = 1.0 x 10(-3); rs84460, OR, 2.32; 95% CI, 1.47-3.67; P < 1.0 x 10(-3)). The largest number of significant associations was found in genes related to infection and inflammation. There were overall a larger number of significant associations in infants than in mothers.
conclusionThese results support a strong role for genes involved in infection and inflammation in the pathogenesis of PTB, particularly IL-12 and IL-12RB, and indicate that in African Americans there may be complementarity of maternal and fetal genetic risks for PTB.
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