ArticleBMC genomics2008
A genome survey of Moniliophthora perniciosa gives new insights into Witches' Broom Disease of cacao.
Article in BMC genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 157 citations in OpenAlex.
- State of the Art of the Molecular Biology of the Interaction between Cocoa and Witches' Broom Disease: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Protium heptaphyllum, a tree native to the Atlantic Forest, is a potential source of compounds against important cocoa phytopathogen.Scientific reports · 2026Article
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- BASIDIN as a New Protein Effector of the Phytopathogen Causing Witche's Broom Disease in Cocoa.International journal of molecular sciences · 2023Article
- Genomic and Pathogenicity Mechanisms of the MainMicroorganisms · 2023Review
- Towards Understanding the Function of Aegerolysins.Toxins · 2022Review
- Draft Genome Sequence of the Ectomycorrhizal Fungus Astraeus odoratus from Northern Thailand.Microbiology resource announcements · 2021Article
- Characterization of the Ergosterol Biosynthesis Pathway in Ceratocystidaceae.Journal of fungi (Basel, Switzerland) · 2021Article
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- Draft genomic sequence of Armillaria gallica 012m: insights into its symbiotic relationship with Gastrodia elata.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- De novo sequencing, assembly and functional annotation of Armillaria borealis genome.BMC genomics · 2020Article
- Brazilian fungal diversity represented by DNA markers generated over 20 years.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Biochemical characterization and inhibition of the alternative oxidase enzyme from the fungal phytopathogen Moniliophthora perniciosa.Communications biology · 2020Article
- The pathogen Moniliophthora perniciosa promotes differential proteomic modulation of cacao genotypes with contrasting resistance to witches´ broom disease.BMC plant biology · 2020Article
- Fungal evolution: major ecological adaptations and evolutionary transitions.Biological reviews of the Cambridge Philosophical Society · 2019Review
- Genome and secretome of Chondrostereum purpureum correspond to saprotrophic and phytopathogenic life styles.PloS one · 2019Article
- Article
- Potential of Yeasts as Biocontrol Agents of the Phytopathogen Causing CacaoFrontiers in microbiology · 2019Review
- Genome sequence and effectorome of Moniliophthora perniciosa and Moniliophthora roreri subpopulations.BMC genomics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 11 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe basidiomycete fungus Moniliophthora perniciosa is the causal agent of Witches' Broom Disease (WBD) in cacao (Theobroma cacao). It is a hemibiotrophic pathogen that colonizes the apoplast of cacao's meristematic tissues as a biotrophic pathogen, switching to a saprotrophic lifestyle during later stages of infection. M. perniciosa, together with the related species M. roreri, are pathogens of aerial parts of the plant, an uncommon characteristic in the order Agaricales. A genome survey (1.9x coverage) of M. perniciosa was analyzed to evaluate the overall gene content of this phytopathogen.
resultsGenes encoding proteins involved in retrotransposition, reactive oxygen species (ROS) resistance, drug efflux transport and cell wall degradation were identified. The great number of genes encoding cytochrome P450 monooxygenases (1.15% of gene models) indicates that M. perniciosa has a great potential for detoxification, production of toxins and hormones; which may confer a high adaptive ability to the fungus. We have also discovered new genes encoding putative secreted polypeptides rich in cysteine, as well as genes related to methylotrophy and plant hormone biosynthesis (gibberellin and auxin). Analysis of gene families indicated that M. perniciosa have similar amounts of carboxylesterases and repertoires of plant cell wall degrading enzymes as other hemibiotrophic fungi. In addition, an approach for normalization of gene family data using incomplete genome data was developed and applied in M. perniciosa genome survey.
conclusionThis genome survey gives an overview of the M. perniciosa genome, and reveals that a significant portion is involved in stress adaptation and plant necrosis, two necessary characteristics for a hemibiotrophic fungus to fulfill its infection cycle. Our analysis provides new evidence revealing potential adaptive traits that may play major roles in the mechanisms of pathogenicity in the M. perniciosa/cacao pathosystem.
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