ReviewAntioxidants & redox signaling2009
Oxidative stress by targeted agents promotes cytotoxicity in hematologic malignancies.
Review in Antioxidants & redox signaling, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Oxidative Stress in Pregnancy.Biomolecules · 2023Review
- Article
- Pseurotin D Induces Apoptosis through Targeting Redox Sensitive Pathways in Human Lymphoid Leukemia Cells.Antioxidants (Basel, Switzerland) · 2021Article
- Suppression of multiple myeloma by mitochondrial targeting.Scientific reports · 2021Article
- Protein Carbonylation and Lipid Peroxidation in Hematological Malignancies.Antioxidants (Basel, Switzerland) · 2020Review
- Effects of 5'-azacytidine and alendronate on a hepatocellular carcinoma cell line: a proteomics perspective.Molecular and cellular biochemistry · 2015Article
- Article
- Proteomic analysis of gossypol induces necrosis in multiple myeloma cells.BioMed research international · 2014Article
- Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomib.Leukemia · 2013Article
- Redox regulation of Janus kinase: The elephant in the room.JAK-STAT · 2013Review
- The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies.Free radical biology & medicine · 2013Article
- Azacytidine induces necrosis of multiple myeloma cells through oxidative stress.Proteome science · 2013Article
- Article
- Article
- Resveratrol sensitizes acute myelogenous leukemia cells to histone deacetylase inhibitors through reactive oxygen species-mediated activation of the extrinsic apoptotic pathway.Molecular pharmacology · 2012Article
- Article
- Reactive oxygen species regulate nucleostemin oligomerization and protein degradation.The Journal of biological chemistry · 2011Article
- Article
- Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors.Journal of biomedicine & biotechnology · 2011Review
- PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells.International journal of cell biology · 2010Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The past decade has seen an exponential increase in the number of cancer therapies with defined molecular targets. Interestingly, many of these new agents are also documented to raise levels of intracellular reactive oxygen species (ROS) in addition to inhibiting a biochemical target. In most cases, the exact link between the primary target of the drug and effects on cellular redox status is unknown. However, it is important to understand the role of oxidative stress in promoting cytotoxicity by these agents, because the design of multiregimen strategies could conceivably build on these redox alterations. Also, drug resistance mediated by antioxidant defenses could potentially be anticipated and circumvented with improved knowledge of the redox-related effects of these targeted agents. Given the large number of targeted chemotherapies, in this review, we focus on selected agents that have shown promise in hematologic malignancies: proteasome inhibitors, histone deacetylase inhibitors, Bcl-2-targeted agents, and a kinase inhibitor called adaphostin. Despite structural differences within classes of these compounds, a commonality of causing increased oxidative stress exists, which contributes to induction of cell death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.