ArticlePLoS biology2008
A novel gene family controls species-specific morphological traits in Hydra.
Article in PLoS biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
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- The Lost and Found: Unraveling the Functions of Orphan Genes.Journal of developmental biology · 2023Review
- A chromosome-scale epigenetic map of theGenome research · 2023Article
- The transcription factor Zic4 promotes tentacle formation and prevents epithelial transdifferentiation inScience advances · 2022Article
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- Identification, Characterization and Function of Orphan Genes Among the Current Cucurbitaceae Genomes.Frontiers in plant science · 2022Article
- Conserved noncoding sequences provide insights into regulatory sequence and loss of gene expression in maize.Genome research · 2021Article
- The myxozoan minicollagen gene repertoire was not simplified by the parasitic lifestyle: computational identification of a novel myxozoan minicollagen gene.BMC genomics · 2021Article
- Many, but not all, lineage-specific genes can be explained by homology detection failure.PLoS biology · 2020Article
- Housing microbial symbionts: evolutionary origins and diversification of symbiotic organs in animals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Bacteria- and temperature-regulated peptides modulate β-catenin signaling inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Dynamic interactions within the host-associated microbiota cause tumor formation in the basal metazoan Hydra.PLoS pathogens · 2020Article
- Identifying the princes base on Altmetrics: An awakening mechanism of sleeping beauties from the perspective of social media.PloS one · 2020Article
- Transgenesis in Hydra to characterize gene function and visualize cell behavior.Nature protocols · 2019Article
- Article
- Differential regulation of myc homologs by Wnt/β-Catenin signaling in the early metazoan Hydra.The FEBS journal · 2019Article
- A morphological novelty evolved by co-option of a reduced gene regulatory network and gene recruitment in a beetle.Proceedings. Biological sciences · 2018Article
- Taxonomically Restricted Genes Are Fundamental to Biology and Evolution.Frontiers in genetics · 2018Article
- A database for orphan genes in Poaceae.Experimental and therapeutic medicine · 2017Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the molecular events that underlie the evolution of morphological diversity is a major challenge in biology. Here, to identify genes whose expression correlates with species-specific morphologies, we compared transcriptomes of two closely related Hydra species. We find that species-specific differences in tentacle formation correlate with expression of a taxonomically restricted gene encoding a small secreted protein. We show that gain of function induces changes in morphology that mirror the phenotypic differences observed between species. These results suggest that "novel" genes may be involved in the generation of species-specific morphological traits.
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