ArticleJournal of molecular evolution2008
Analysis of the DDE motif in the Mutator superfamily.
Article in Journal of molecular evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Divergent Evolutionary Profile ofAnimals : an open access journal from MDPI · 2026Article
- Article
- Landscape of mobile genetic elements and their antibiotic resistance cargo in prokaryotic genomes.Nucleic acids research · 2022Article
- Structures of ISCth4 transpososomes reveal the role of asymmetry in copy-out/paste-in DNA transposition.The EMBO journal · 2021Article
- Systematic prediction of genes functionally associated with bacterial retrons and classification of the encoded tripartite systems.Nucleic acids research · 2020Article
- Evolution ofMobile DNA · 2019Article
- Bacterial insertion sequences: their genomic impact and diversity.FEMS microbiology reviews · 2014Review
- The diversity of prokaryotic DDE transposases of the mutator superfamily, insertion specificity, and association with conjugation machineries.Genome biology and evolution · 2014Article
- Article
- TED, an autonomous and rare maize transposon of the mutator superfamily with a high gametophytic excision frequency.The Plant cell · 2013Article
- The Oxytricha trifallax macronuclear genome: a complex eukaryotic genome with 16,000 tiny chromosomes.PLoS biology · 2013Article
- A gene family derived from transposable elements during early angiosperm evolution has reproductive fitness benefits in Arabidopsis thaliana.PLoS genetics · 2012Article
- Identification of an active new mutator transposable element in maize.G3 (Bethesda, Md.) · 2011Article
- The catalytic domain of all eukaryotic cut-and-paste transposase superfamilies.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- Characterization of the transposase encoded by IS256, the prototype of a major family of bacterial insertion sequence elements.Journal of bacteriology · 2010Article
- Phantom, a new subclass of Mutator DNA transposons found in insect viruses and widely distributed in animals.Genetics · 2010Article
- Integrating prokaryotes and eukaryotes: DNA transposases in light of structure.Critical reviews in biochemistry and molecular biology · 2010Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The eukaryotic Mutator family of transposable elements is widespread in plants. Active or potentially active copies are also found in fungi and protozoans, and sequences related to this family have been detected in metazoans as well. Members of this family are called Mutator-like elements (MULEs). They encode transposases, which contain a region conserved with transposases of the IS256 prokaryotic family, known to harbor a DDE catalytic domain. Different DDE or D34E motifs have been proposed in some groups of eukaryotic MULEs based on primary sequence conservation. On a large number of protein sequences related to, and representative of, all MULE families, we analyzed global conservation, the close environment of different acidic residues and the secondary structure. This allowed us to identify a potential DDE motif that is likely to be homologous to the one in IS256-like transposases. The characteristics of this motif are depicted in each known family of MULEs. Different hypotheses about the evolution of this triad are discussed.
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