ArticlePflugers Archiv : European journal of physiology2009
Actions of aldosterone in the cardiovascular system: the good, the bad, and the ugly?
Article in Pflugers Archiv : European journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 75 citations in OpenAlex.
- Effects of Vitamin D Supplementation on Plasma Aldosterone and Renin-A Randomized Placebo-Controlled Trial.Journal of clinical hypertension (Greenwich, Conn.) · 2016Trial
- A comprehensive review of finerenone-a third-generation non-steroidal mineralocorticoid receptor antagonist.Frontiers in cardiovascular medicine · 2024Review
- Potential Impact of Non-Steroidal Mineralocorticoid Receptor Antagonists in Cardiovascular Disease.International journal of molecular sciences · 2023Review
- Importance of Micromilieu for Pathophysiologic Mineralocorticoid Receptor Activity-When the Mineralocorticoid Receptor Resides in the Wrong Neighborhood.International journal of molecular sciences · 2022Review
- Serum Calcification Propensity and Calcification of the Abdominal Aorta in Patients With Primary Aldosteronism.Frontiers in cardiovascular medicine · 2022Article
- Safety, Tolerability, and Pharmacokinetics of the Mineralocorticoid Receptor Modulator AZD9977 in Healthy Men: A Phase I Multiple Ascending Dose Study.Clinical and translational science · 2020Article
- Chemogenetic activation of adrenocortical Gq signaling causes hyperaldosteronism and disrupts functional zonation.The Journal of clinical investigation · 2020Article
- Article
- Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 2.Scientific reports · 2017Article
- Biventricular Cardiac Hypertrophy in a Patient with Primary Aldosteronism and Atrial Septal Defect.The American journal of case reports · 2017Article
- Spot urine sodium excretion as prognostic marker in acutely decompensated heart failure: the spironolactone effect.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
- Aldosterone-to-Renin Ratio Is Associated With Reduced 24-Hour Heart Rate Variability and QTc Prolongation in Hypertensive Patients.Medicine · 2016Article
- Modulation of Immunity and Inflammation by the Mineralocorticoid Receptor and Aldosterone.BioMed research international · 2015Review
- Moderate inappropriately high aldosterone/NaCl constellation in mice: cardiovascular effects and the role of cardiovascular epidermal growth factor receptor.Scientific reports · 2014Article
- Aldosterone to active renin ratio is associated with nocturnal blood pressure in obese and treated hypertensive patients: the Styrian Hypertension Study.Journal of clinical hypertension (Greenwich, Conn.) · 2014Article
- Aldosterone and cortisol affect the risk of sudden cardiac death in haemodialysis patients.European heart journal · 2013Article
- Acute and chronic regulation of aldosterone production.Molecular and cellular endocrinology · 2012Review
- Central regulation of blood pressure by the mineralocorticoid receptor.Molecular and cellular endocrinology · 2012Review
- An emerging concept of vascular salt sensitivity.F1000 biology reports · 2012Article
- The role of the renin-angiotensin system blocking in the management of atrial fibrillation.Journal of drug assessment · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aldosterone and its receptor, the mineralocorticoid receptor (MR), play a key role in the regulation of reno-cardiovascular function as well as in the regulation of normal and abnormal reno-cardiovascular function, which are responsible for the variety of its functional responses. The underlying mechanisms are of genomic and nongenotropic nature. Prevention of critical arterial hypotension by NaCl retention and regulation of potassium homeostasis, which is of eminent importance for cardiovascular electrophysiology and rhythmogenesis, represent the good face of aldosterone in the cardiovascular system. Triggering of persistent arterial hypertension with all the detrimental secondary effects on heart, kidney, vessels, and brain represents the bad face of aldosterone/MR in the cardiovascular system. Blood pressure-independent reno-cardiovascular end organ damage represents the ugly face of MR activation and does not depend on elevated aldosterone concentrations. In this way, aldosterone/MR induces or facilitates inflammatory and fibrotic processes in a permissive milieu, created for example by angiotensin II or NaCl and characterized by enhanced oxidative stress, in vascular walls.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.