Evidence map›Paper›PMID 19018479›Full record

ArticleImmunologic research2008

Cancer immunotherapy using Listeria monocytogenes and listerial virulence factors.

Laurence M Wood, Patrick D Guirnalda, Matthew M Seavey, Yvonne Paterson

Open access · bronzeAbstract read
In one paragraph

Article in Immunologic research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 62 citations in OpenAlex.

  1. Review
  2. Review
  3. Listeria monocytogenes: from a saprophytic to a cytosolic virulent pathogen.World journal of microbiology & biotechnology · 2025
    Review
  4. Review
  5. Review
  6. HarnessingArchives of Razi Institute · 2025
    Review
  7. Transforming bacterial pathogens into wonder tools in cancer immunotherapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Dysbiotic microbes and how to find them: a review of microbiome profiling in prostate cancer.Journal of experimental & clinical cancer research : CR · 2022
    Review
  13. Review
  14. Review
  15. Article
  16. Recent trends and advances in microbe-based drug delivery systems.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2019
    Review
  17. Review
  18. Article
  19. Activation of themBio · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Laurence M WoodDepartment of Microbiology, University of Pennsylvania School of Medicine, 323 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA, 19104-6076, USA.
Patrick D Guirnalda
Matthew M Seavey
Yvonne Paterson
University of Pennsylvania · US

Funding

CANCER IMMUNOTHERAPY WITH A LIVE RECOMBINANT VACCINER01CA069632 · NCI · UNIVERSITY OF PENNSYLVANIA · PI PATERSON, YVONNE J · 1996 to 2011
$3.1M
Training in Cancer ImmunopathobiologyT32CA101968 · NCI · UNIVERSITY OF PENNSYLVANIA · PI GREENE, MARK I · 2003 to 2007
$1.6M
NCI NIH HHS R01 CA069632NCI NIH HHS T32 CA101968
6 · The paper itself

Abstract

Our laboratory is interested in how immunogenicity may be modulated in vivo in order to better design more effective immunotherapeutics against cancer. Our main approach is to use a facultative intracellular bacterium, Listeria monocytogenes, which has the unusual ability to live and grow in the cytoplasm of the cell and is thus an excellent vector for targeting passenger antigens to the major histocompatibility complex (MHC) class I pathway of antigen processing with the generation of authentic CTL epitopes. We have used this approach to target tumor antigens expressed on breast, melanoma and cervical cancer. We are also exploring the role of Listerial virulence factors in potentiating adaptive immune responses by activating innate immunity. Specifically, we are using these proteins as adjuvants for B cell lymphomas.

Indexed as

AnimalsBacterial ToxinsBreast NeoplasmsCancer VaccinesFemaleHeat-Shock ProteinsHemolysin ProteinsHumansImmunotherapyListeria monocytogenesLymphoma, Non-HodgkinVirulence FactorsBacterial ToxinsCancer VaccinesHeat-Shock ProteinsHemolysin ProteinshlyA protein, Listeria monocytogenesVirulence Factors

Identifiers

PMID19018479
PMCPMC2763613
OpenAlexW2037018990

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.