ArticleTechniques in coloproctology2008
Local gentamicin reduces perineal wound infection after radiotherapy and abdominoperineal resection.
Article in Techniques in coloproctology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Local Application of Gentamicin in the Prophylaxis of Perineal Wound Infection After Abdominoperineal Resection: A Systematic Review.World journal of surgery · 2015Pooled it
- Antimicrobials as an adjunct to pilonidal disease surgery: a systematic review of the literature.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2013Pooled it
- The gentamicin-collagen implant and the risk of distant metastases of rectal cancer following short-course radiotherapy and curative resection: the long-term outcomes of a randomized study.International journal of colorectal disease · 2018Trial
- Subcutaneous application of gentamicin collagen implants as prophylaxis of surgical site infections in laparoscopic colorectal surgery: a randomized, double-blinded, three-arm trial.Langenbeck's archives of surgery · 2015Trial
- Surgical site infections following short-term radiotherapy and total mesorectal excision: results of a randomized study examining the role of gentamicin collagen implant in rectal cancer surgery.Techniques in coloproctology · 2014Trial
- Laparoscopic perineal hernia repair after abdominoperineal resection.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- The effect of incisional negative pressure wound therapy on the improvement of postoperative cosmetic suture wounds and scar hyperplasia.International wound journal · 2023Article
- Impact of etiology leading to abdominoperineal resection with anterolateral thigh flap reconstruction: A retrospective cohort study.Journal of surgical oncology · 2023Article
- Clinical Efficacy of the Antibiotic-Loaded Collagen Sponge During Arthroscopic Treatment of Acute Septic Arthritis of the Native Knee.Orthopaedic journal of sports medicine · 2022Article
- Treatment of vascular graft infections: gentamicin-coated ePTFE grafts reveals strong antibacterial properties in vitro.Journal of materials science. Materials in medicine · 2022Article
- Clinical effectiveness of omental transposition in facilitating perineal wound healing after abdominoperineal resection: a systematic review.Yeungnam University journal of medicine · 2021Article
- Incisional negative pressure wound therapy to reduce perineal wound infection after abdominoperineal resection.International wound journal · 2021Article
- Wound infection in colorectal cancer resections through a laparoscopic approach: a single-center prospective observational study of over 3000 cases.Discover oncology · 2021Article
- Ultralow anterior resection with implantation of gentamicin-collagen sponge and no defunctioning stoma: anastomotic leakage and local cancer relapse.Radiology and oncology · 2019Article
- Simultaneous stoma reinforcement and perineal reconstruction with biological mesh - A multicentre prospective observational study.Annals of medicine and surgery (2012) · 2019Article
- Extended pelvic resection for rectal and anal canal tumors is a significant risk factor for perineal wound infection: a retrospective cohort study.Surgery today · 2018Article
- Collagen implant with gentamicin sulphate as an option to treat a neuroischaemic diabetic foot ulcer: Case report.International journal of surgery case reports · 2016Article
- Biologic Mesh Reconstruction of the Pelvic Floor after Extralevator Abdominoperineal Excision: A Systematic Review.Frontiers in surgery · 2016Review
- The gentamicin-collagen sponge for surgical site infection prophylaxis in colorectal surgery: a prospective case-matched study of 606 cases.International journal of colorectal disease · 2013Article
- Local application of gentamicin collagen implants in the prophylaxis of surgical site infections following gastrointestinal surgery: a review of clinical experience.Techniques in coloproctology · 2010Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPerineal wound complications are frequently observed after abdominoperineal resection (APR) for rectal cancer, especially in preoperatively irradiated patients. This is the first study to investigate whether local application of gentamicin-impregnated collagen fleece reduces deep perineal wound infection after APR for rectal cancer following short-term radiotherapy.
methodsBetween 2003 and 2007, a consecutive series of 40 patients underwent an APR for rectal cancer after short-course radiotherapy in our hospital. Of these patients, 19 received supplementary application of three reabsorbable gentamicin-impregnated collagen fleece sponges into the sacral cavity before closure of the perineum (group A), and 21 patients underwent primary closure of the perineal wound and served as a control group (group B). All patients received sacral drainage. A superficial perineal wound infection was defined as cellulitis with no evidence of deep tissue infection. A deep perineal wound infection was defined as skin and subcutaneous tissue breakdown with infection extending deep into the subcutaneous tissue or a wound abscess.
resultsThe two groups were comparable regarding age, sex, tumour stage and level of the tumour. No postoperative mortality was observed in either group. Primary wound healing occurred in 16 patients (84%) in the gentamicin group and 9 patients (43%%) in the control group (p=0.01). The incidences of superficial perineal wound complications were 11% (two patients) in group A who received local application of gentamicin and 29% (six patients) in group B (p=0.15). Six patients (29%) in group B developed a deep infection or wound abscess, resulting in full dehiscence of the wound and sacral cavity. This devastating complication occurred in only one patient (5%) in group A (p=0.05). In most patients deep perineal wound infection was treated with vacuum therapy or drainage. The mean hospital stay of the gentamicin group was 15 days and of the control group 25 days (p=0.04).
conclusionsBased on the results of this study, we recommend local application of gentamicin in the sacral cavity in patients who undergo abdominoperineal resection after shortterm radiotherapy.
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