ArticleBritish journal of cancer2008
Expression of the zinc-finger transcription factor Snail in adrenocortical carcinoma is associated with decreased survival.
Article in British journal of cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- A transcription factor signature predicts the survival of patients with adrenocortical carcinoma.PeerJ · 2021Article
- Expression of FSCN1 and FOXM1 are associated with poor prognosis of adrenocortical carcinoma patients.BMC cancer · 2019Article
- Therapeutic Perspectives of Molecules fromMolecules (Basel, Switzerland) · 2019Review
- Article
- PLCE1 Promotes Esophageal Cancer Cell Progression by Maintaining the Transcriptional Activity of Snail.Neoplasia (New York, N.Y.) · 2017Article
- Investigation of N-cadherin/β-catenin expression in adrenocortical tumors.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Clinical significance of zinc-finger E-box binding homeobox 1 mRNA levels in peritoneal washing for gastric cancer.Molecular and clinical oncology · 2015Article
- Histone Demethylases in Colon Cancer.Current colorectal cancer reports · 2014Article
- Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells.Oncogene · 2013Article
- LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer.British journal of cancer · 2013Article
- High expression of ZEB1 correlates with liver metastasis and poor prognosis in colorectal cancer.Oncology letters · 2013Article
- Molecular markers of adrenocortical tumors.Journal of surgical oncology · 2012Review
- Epithelial-mesenchymal transition is a critical step in tumorgenesis of pancreatic neuroendocrine tumors.Cancers · 2012Article
- Clinical impact of TP53 alterations in adrenocortical carcinomas.Langenbeck's archives of surgery · 2012Article
- Review
- Transcriptional factors associated with epithelial-mesenchymal transition in choroidal neovascularization.Molecular vision · 2011Article
- Tuberin regulates E-cadherin localization: implications in epithelial-mesenchymal transition.The American journal of pathology · 2010Article
- Epithelial-mesenchymal transition in cancer development and its clinical significance.Cancer science · 2010Review
- Induction of epithelial mesenchimal transition and vasculogenesis in the lenses of Dbl oncogene transgenic mice.PloS one · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we evaluate whether Snail is expressed in adrenocortical cancer (ACC) and if its expression is related to patient outcome. One of the best known functions of the zinc-finger transcription factor Snail is to induce epithelial-to-mesenchymal transition (EMT). Increasing evidence suggests that EMT plays a pivotal role in tumour progression and metastatic spread. Snail and E-cadherin expression were assessed by immunohistochemistry in 26 resected ACCs and real-time quantitative RT-PCR expression analysis was performed. Data were correlated with clinical outcome and in particular with overall patient survival. Seventeen of 26 (65%) ACC tumour samples expressed Snail when assessed by immunohistochemistry. Snail expression was neither detected in normal adrenocortical tissue, nor in benign adrenocortical adenomas. Expression levels were confirmed on the mRNA level by Real-Time-PCR. Survival rates were significantly decreased in Snail-positive tumours compared to Snail-negative tumours: 10 out of 16 vs one out of eight patients succumbed to disease after a median follow up of 14.5 and 28.5 months, respectively (P=0.03). Patients with Snail-expressing ACCs presented in advanced disease (11 out of 12 vs 6 out of 14, P=0.01) and tend to develop distant metastases more frequently than patients with negative staining (7 out of 11 vs two out of eight, P=0.19). In conclusion, we describe for the first time that Snail is expressed in a large subset of ACCs. Furthermore, Snail expression is associated with decreased survival, advanced disease and higher risk of developing distant metastases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.