ArticlePsychiatric genetics2008
Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder.
Article in Psychiatric genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Association between brain-derived neurotrophic factor genetic polymorphism Val66Met and susceptibility to bipolar disorder: a meta-analysis.BMC psychiatry · 2014Pooled it
- Interaction between stress and the BDNF Val66Met polymorphism in depression: a systematic review and meta-analysis.BMC medicine · 2014Pooled it
- Genetic predictors of lithium response in an ethiopian cohort of patients with bipolar disorder.Annals of general psychiatry · 2026Article
- BDNF/BDNF-AS Gene Polymorphisms Modulate Treatment Response and Remission in Bipolar Disorder: A Randomized Clinical Trial.Journal of personalized medicine · 2025Article
- The Genetic Side of the Mood: A Scientometric Review of the Genetic Basis of Mood Disorders.Genes · 2023Review
- Association of intron 4 VNTR polymorphism in theNeurosciences (Riyadh, Saudi Arabia) · 2022Article
- The genetics of bipolar disorder.Molecular psychiatry · 2020Review
- BDNF genetic variants and methylation: effects on cognition in major depressive disorder.Translational psychiatry · 2019Article
- Association of CACNA1C Variants with Bipolar Disorder in the Korean Population.Psychiatry investigation · 2016Article
- Reduced hippocampus volume and memory performance in bipolar disorder patients carrying the BDNF val66met met allele.Journal of affective disorders · 2016Article
- Clinical and genetic factors associated with suicide in mood disorder patients.European archives of psychiatry and clinical neuroscience · 2016Article
- NRSF and BDNF polymorphisms as biomarkers of cognitive dysfunction in adults with newly diagnosed epilepsy.Epilepsy & behavior : E&B · 2016Article
- BDNF promoter methylation and genetic variation in late-life depression.Translational psychiatry · 2015Article
- Investigating the mechanism(s) underlying switching between states in bipolar disorder.European journal of pharmacology · 2015Review
- Age-modulated association between prefrontal NAA and the BDNF gene.The international journal of neuropsychopharmacology · 2013Article
- Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction.Pharmacogenomics · 2013Article
- Evidence for single nucleotide polymorphisms and their association with bipolar disorder.Neuropsychiatric disease and treatment · 2013Review
- A polymorphism associated with depressive disorders differentially regulates brain derived neurotrophic factor promoter IV activity.Biological psychiatry · 2012Article
- BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity.Molecular psychiatry · 2012Review
- Bipolar disorder, brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and brain morphology.PloS one · 2012Article
Corrections and comments
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Authors and funding
22 authors at 15 institutions in 1 country.
Funding
Abstract
objectiveBrain-derived neurotrophic factor (BDNF) plays an important role in the survival, differentiation, and outgrowth of select peripheral and central neurons throughout adulthood. Growing evidence suggests that BDNF is involved in the pathophysiology of mood disorders.
methodsTen single nucleotide polymorphisms (SNPs) across the BDNF gene were genotyped in a sample of 1749 Caucasian Americans from 250 multiplex bipolar families. Family-based association analysis was used with three hierarchical bipolar disorder models to test for an association between SNPs in BDNF and the risk of bipolar disorder. In addition, an exploratory analysis was performed to test for an association of the SNPs in BDNF and the phenotypes of rapid cycling and episode frequency.
resultsEvidence of association (P<0.05) was found with several of the SNPs using multiple models of bipolar disorder; one of these SNPs also showed evidence of association (P<0.05) with rapid cycling.
conclusionThese results provide further evidence that variation in BDNF affects the risk for bipolar disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.