ArticleChest2009
Genetic associations with hypoxemia and pulmonary arterial pressure in COPD.
Article in Chest, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Pooled it
- Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease.American journal of respiratory cell and molecular biology · 2014Trial
- Multi-Omics Identification of Biomarkers for High-Altitude Pulmonary Hypertension.Journal of cardiovascular development and disease · 2026Article
- Hypoxia: a critical pathophysiological driver in respiratory inflammatory diseases.Military Medical Research · 2026Review
- Clinical characteristics and predictors of pulmonary hypertension in chronic obstructive pulmonary disease at different altitudes.BMC pulmonary medicine · 2023Article
- Applying whole-genome sequencing in relation to phenotype and outcomes in siblings with cystic fibrosis.Cold Spring Harbor molecular case studies · 2020Article
- Notch activation of CaHypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Serpine2 deficiency results in lung lymphocyte accumulation and bronchus-associated lymphoid tissue formation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension.American journal of respiratory cell and molecular biology · 2015Article
- Genetic influences on right ventricular systolic pressure (RVSP) in chronic obstructive pulmonary disease (COPD).BMC pulmonary medicine · 2012Article
- Association of SERPINE2 gene with the risk of chronic obstructive pulmonary disease and spirometric phenotypes in northern Han Chinese population.Molecular biology reports · 2012Article
- The association of SERPINE2 gene with COPD in a Chinese Han population.Yonsei medical journal · 2011Article
- Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies.Analytical biochemistry · 2011Article
- Hypoxemia in patients with COPD: cause, effects, and disease progression.International journal of chronic obstructive pulmonary disease · 2011Review
- Multiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes.PloS one · 2011Article
- Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases.BMC medical genetics · 2010Article
- [Obstructive pulmonary diseases and pulmonary hypertension].Der Internist · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHypoxemia, hypercarbia, and pulmonary arterial hypertension are known complications of advanced COPD. We sought to identify genetic polymorphisms associated with these traits in a population of patients with severe COPD from the National Emphysema Treatment Trial (NETT).
methodsIn 389 participants from the NETT Genetics Ancillary Study, single-nucleotide polymorphisms (SNPs) were genotyped in five candidate genes previously associated with COPD susceptibility (EPHX1, SERPINE2, SFTPB, TGFB1, and GSTP1). Linear regression models were used to test for associations among these SNPs and three quantitative COPD-related traits (Pao(2), Paco(2), and pulmonary artery systolic pressure). Genes associated with hypoxemia were tested for replication in probands from the Boston Early-Onset COPD Study.
resultsIn the NETT Genetics Ancillary Study population, SNPs in microsomal epoxide hydrolase (EPHX1) [p = 0.01 to 0.04] and serpin peptidase inhibitor, clade E, member 2 (SERPINE2) [p = 0.04 to 0.008] were associated with hypoxemia. One SNP within surfactant protein B (SFTPB) was associated with pulmonary artery systolic pressure (p = 0.01). In probands from the Boston Early-Onset COPD Study, SNPs in EPHX1 and in SERPINE2 were associated with the requirement for supplemental oxygen.
conclusionsIn participants with severe COPD, SNPs in EPHX1 and SERPINE2 were associated with hypoxemia in two separate study populations, and SNPs from SFTPB were associated with pulmonary artery pressure in the NETT participants.
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Registered trials
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