Peroxynitrite and opiate antinociceptive tolerance: a painful reality.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

16 citing papers in PubMed.

1. Widespread pain syndrome in long COVID-19: melatonin as an adjuvant treatment.Frontiers in pain research (Lausanne, Switzerland) · 2025
   Review
2. Protective effects of pistachio hydroalcoholic extract on morphine-induced analgesic tolerance and dependence: investigating the impact of oxidative stress.Research in pharmaceutical sciences · 2024
   Article
3. The cell-permeant antioxidant D-thiol ester D-cysteine ethyl ester overcomes physical dependence to morphine in male Sprague Dawley rats.Frontiers in pharmacology · 2024
   Article
4. Accelerated brain aging with opioid misuse and HIV: New insights on the role of glially derived pro-inflammation mediators and neuronal chloride homeostasis.Current opinion in neurobiology · 2023
   Review
5. Opioid and neuroHIV Comorbidity - Current and Future Perspectives.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
   Review
6. Inhibition of Spinal Oxidative Stress by Bergamot Polyphenolic Fraction Attenuates the Development of Morphine Induced Tolerance and Hyperalgesia in Mice.PloS one · 2016
   Article
7. Ginger (zingiber officinale roscoe) prevents morphine-induced addictive behaviors in conditioned place preference test in rats.Addiction & health · 2014
   Article
8. Morphine-enhanced apoptosis in selective brain regions of neonatal rats.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2013
   Article
9. Co-activation of μ- and δ-opioid receptors elicits tolerance to morphine-induced ventilatory depression via generation of peroxynitrite.Respiratory physiology & neurobiology · 2013
   Article
10. Neonatal morphine administration leads to changes in hippocampal BDNF levels and antioxidant enzyme activity in the adult life of rats.Neurochemical research · 2013
    Article
11. Retooling manganese(III) porphyrin-based peroxynitrite decomposition catalysts for selectivity and oral activity: a potential new strategy for treating chronic pain.Journal of medicinal chemistry · 2011
    Article
12. Protective role of taurine against morphine-induced neurotoxicity in C6 cells via inhibition of oxidative stress.Neurotoxicity research · 2011
    Article
13. Roles of reactive oxygen and nitrogen species in pain.Free radical biology & medicine · 2011
    Review
14. Manganese(III) complexes of bis(hydroxyphenyl)dipyrromethenes are potent orally active peroxynitrite scavengers.Journal of the American Chemical Society · 2011
    Article
15. Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance.Neuroscience · 2009
    Article
16. Searching for new strategies for the pharmacological treatment of chronic pain.Missouri medicine
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

1 author.

Funding

Abstract

PubMed holds no abstract for this paper.

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