ArticleOral diseases2009
Effect of HAART on salivary gland function in the Women's Interagency HIV Study (WIHS).
Article in Oral diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
- Trial
- Longitudinal Predictors of Dental Caries, Periodontal Disease and Oral Health Quality of Life in People with HIV on ART: The OHART study.Research square · 2026Article
- Xerostomia and associated factors among adults with HIV on HAART attending voluntary counseling and testing (VCT) clinics in Dar Es Salaam.BMC oral health · 2025Article
- Health-related quality of life and associated factors among people living with HIV/AIDS in Sichuan, China: A cross-sectional study.Frontiers in public health · 2023Article
- Review
- Altered Salivary Microbiome in the Early Stage of HIV Infections among Young Chinese Men Who Have Sex with Men (MSM).Pathogens (Basel, Switzerland) · 2020Article
- Salivary flow, amylase, and total protein in hospitalized patients with HIV infection / AIDS complications.African health sciences · 2020Article
- Current trends and new developments in HIV research and periodontal diseases.Periodontology 2000 · 2020Review
- Prevalence and factors associated with dental caries in patients attending an HIV care clinic in Uganda: a cross sectional study.BMC oral health · 2019Article
- Oral manifestations, salivary flow rates and Candida species in Thai HIV-infected patients.Journal of clinical and experimental dentistry · 2019Article
- Extensive dental caries in a HIV positive adult patient on ART; case report and literature review.BMC oral health · 2018Review
- Contribution of HIV Infection, AIDS, and Antiretroviral Therapy to Exocrine Pathogenesis in Salivary and Lacrimal Glands.International journal of molecular sciences · 2018Review
- Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health.Free radical biology & medicine · 2017Review
- Dental Health Status of HIV-Positive Patients and Related Variables in Southeast Iran.International journal of high risk behaviors & addiction · 2016Article
- Pseudomembranous Type of Oral Candidiasis is Associated with Decreased Salivary Flow Rate and Secretory Immunoglobulin A Levels.Mycopathologia · 2015Article
- Article
- Differences in Salivary Flow Level, Xerostomia, and Flavor Alteration in Mexican HIV Patients Who Did or Did Not Receive Antiretroviral Therapy.AIDS research and treatment · 2013Article
- HIV infection affects Streptococcus mutans levels, but not genotypes.Journal of dental research · 2012Article
- Oral and systemic health correlates of HIV-1 shedding in saliva.Journal of dental research · 2010Article
- Effects of long-term use of HAART on oral health status of HIV-infected subjects.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveTo determine the impact of highly active antiretroviral therapy (HAART) on salivary gland function in human immunodeficiency virus (HIV) positive women from the Women's Interagency HIV Study (WIHS).
designLongitudinal cohort study. SUBJECTS AND
methodsA total of 668 HIV positive women from the WIHS cohort with an initial and at least one follow-up oral sub-study visit contributed 5358 visits. Salivary gland function was assessed based on a dry mouth questionnaire, whole unstimulated and stimulated salivary flow rates, salivary gland enlargement or tenderness and lack of saliva on palpation of the major salivary glands.
main outcome measuresChanges in unstimulated and stimulated flow rates at any given visit from that of the immediate prior visit (continuous variables). The development of self-reported dry mouth (present/absent), enlargement or tenderness of salivary glands (present/absent), and absence of secretion on palpation of the salivary glands were binary outcomes (yes/no).
resultsProtease Inhibitor (PI) based HAART was a significant risk factor for developing decreased unstimulated (P = 0.01) and stimulated (P = 0.0004) salivary flow rates as well as salivary gland enlargement (P = 0.006) as compared with non-PI based HAART.
conclusionsPI-based HAART therapy is a significant risk factor for developing reduced salivary flow rates and salivary gland enlargement in HIV positive patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.