Evidence map›Paper›PMID 19016270›Full record

Trial reportCancer2008

Psychologic intervention improves survival for breast cancer patients: a randomized clinical trial.

Barbara L Andersen, Hae-Chung Yang, William B Farrar, Deanna M Golden-Kreutz, Charles F Emery, Lisa M Thornton, Donn C Young, William E Carson

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 186 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed, 10 pooled it
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05055375 unknown statusnot on this mapstarted 2019, after this paper: background citation

The Psychology of Chinese Breast Cancer Patients

TypeobservationalSponsorMa Fei，MDRan2019 to 2021Enrolled300ConditionsBreast CancerArmsquestionnaire survey
NCT07107594 narecruitingnot on this mapstarted 2025, after this paper: background citation

Multimodal Intervention During Neoadjuvant Chemotherapy in Patients With Early-breast Cancer as a Strategy to Improve Treatment Response: DIANA Trial (Multimodal Prehabilitation: DIet, ANxiety Control Psychotherapy, Physical Activity)

TypeinterventionalSponsorHospital Clinic of BarcelonaRan2025 to 2028Enrolled214ConditionsBreast Cancer Early Stage Breast Cancer (Stage 1-3), PrehabilitationArmsMultimodal prehabilitation
3 · Its place in the literature

Who cites it

186 citing papers in PubMed, 10 syntheses or guidelines pooled it, 489 citations in OpenAlex.

  1. Pooled it
  2. Psychological interventions for women with non-metastatic breast cancer.The Cochrane database of systematic reviews · 2023
    Pooled it
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  6. Guideline
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  8. Psychological interventions for women with metastatic breast cancer.The Cochrane database of systematic reviews · 2013
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  17. Relationship between social support, quality of life, and Th2 cytokines in a biobehavioral cancer survivorship trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
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  19. Lemons to lemonade: Effects of a biobehavioral intervention for cancer patients on later life changes.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2019
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126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Barbara L AndersenDepartment of Psychology, Ohio State University, Columbus, OH 43210-1222, USA. Andersen.1@osu.edu
Hae-Chung Yang
William B Farrar
Deanna M Golden-Kreutz
Charles F Emery
Lisa M Thornton
Donn C Young
William E Carson
The Ohio State University · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
TWO SIGNAL REQUIREMENT FOR NATURAL KILLER IMMUNITYP01CA095426 · NCI · OHIO STATE UNIVERSITY · PI CARSON, WILLIAM E. · 2002 to 2016
$29.6M
University of Iowa Clinical and Translational Science Program (TL1)UL1RR025755 · NCRR · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2008 to 2011
$26.3M
Psychological intervention for women with breast cancerR01CA092704 · NCI · OHIO STATE UNIVERSITY · PI ANDERSEN, BARBARA L. · 2001 to 2005
$4.2M
A Program of Immune-Based Treatments for CancerK24CA093670 · NCI · OHIO STATE UNIVERSITY · PI CARSON, WILLIAM E. · 2002 to 2012
$1.7M
Biobehavioral Responses to CancerK05CA098133 · NCI · OHIO STATE UNIVERSITY · PI ANDERSEN, BARBARA L. · 2004 to 2014
$1.5M
PSYCHOLOGICAL INTERVENTION FOR WOMEN WITH BREAST CANCERR01MH051487 · NIMH · OHIO STATE UNIVERSITY · PI ANDERSEN, BARBARA L. · 1996 to 2000
$791k
NCI NIH HHS K05 CA098133NCI NIH HHS K24 CA093670NCI NIH HHS KA24 CA93670NCI NIH HHS P01 CA095426NCI NIH HHS P01 CA95426NCI NIH HHS P30 CA016058NCI NIH HHS P30 CA16058NCI NIH HHS R01 CA092704NCI NIH HHS R01 CA92704NCRR NIH HHS UL1 RR025755NIMH NIH HHS R01 MH051487NIMH NIH HHS R01 MH51487
6 · The paper itself

Abstract

backgroundThe question of whether stress poses a risk for cancer progression has been difficult to answer. A randomized clinical trial tested the hypothesis that cancer patients coping with their recent diagnosis but receiving a psychologic intervention would have improved survival compared with patients who were only assessed.

methodsA total of 227 patients who were surgically treated for regional breast cancer participated. Before beginning adjuvant cancer therapies, patients were assessed with psychologic and behavioral measures and had a health evaluation, and a 60-mL blood sample was drawn. Patients were randomized to Psychologic Intervention plus assessment or Assessment only study arms. The intervention was psychologist led; conducted in small groups; and included strategies to reduce stress, improve mood, alter health behaviors, and maintain adherence to cancer treatment and care. Earlier articles demonstrated that, compared with the Assessment arm, the Intervention arm improved across all of the latter secondary outcomes. Immunity was also enhanced.

resultsAfter a median of 11 years of follow-up, disease recurrence was reported to occur in 62 of 212 (29%) women and death was reported for 54 of 227 (24%) women. Using Cox proportional hazards analysis, multivariate comparison of survival was conducted. As predicted, patients in the Intervention arm were found to have a reduced risk of breast cancer recurrence (hazards ratio [HR] of 0.55; P = .034) and death from breast cancer (HR of 0.44; P = .016) compared with patients in the Assessment only arm. Follow-up analyses also demonstrated that Intervention patients had a reduced risk of death from all causes (HR of 0.51; P = .028).

conclusionsPsychologic interventions as delivered and studied here can improve survival.

Indexed as

Psychotherapy, GroupAdultAgedBreast NeoplasmsFemaleFollow-Up StudiesHumansInterview, PsychologicalMiddle AgedNeoplasm Recurrence, LocalProportional Hazards ModelsStress, Psychological

Identifiers

PMID19016270
PMCPMC2661422
OpenAlexW2168881894

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.