ArticleJournal of neurovirology2008
Toll-like receptor 7 is not necessary for retroviral neuropathogenesis but does contribute to virus-induced neuroinflammation.
Article in Journal of neurovirology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- TLR7 is expressed by support cells, but not sensory neurons, in ganglia.Journal of neuroinflammation · 2021Article
- SARM1, Not MyD88, Mediates TLR7/TLR9-Induced Apoptosis in Neurons.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Age-related differences in neuroinflammatory responses associated with a distinct profile of regulatory markers on neonatal microglia.Journal of neuroinflammation · 2014Article
- Innate immune activation in the pathogenesis of a murine model of globoid cell leukodystrophy.The American journal of pathology · 2014Article
- Human endogenous retroviruses and the nervous system.Handbook of clinical neurology · 2014Review
- Relationship of plasma cytokines and clinical biomarkers to memory performance in HIV.Journal of neuroimmunology · 2013Article
- Toll-like receptor 7 suppresses virus replication in neurons but does not affect viral pathogenesis in a mouse model of Langat virus infection.The Journal of general virology · 2013Article
- HIV-1 Tat C-mediated regulation of tumor necrosis factor receptor-associated factor-3 by microRNA 32 in human microglia.Journal of neuroinflammation · 2012Article
- TLR7 and TLR9 trigger distinct neuroinflammatory responses in the CNS.The American journal of pathology · 2011Article
- Plasma cytokine concentrations associated with HIV/hepatitis C coinfection are related to attention, executive and psychomotor functioning.Journal of neuroimmunology · 2011Article
- Poly-thymidine oligonucleotides mediate activation of murine glial cells primarily through TLR7, not TLR8.PloS one · 2011Article
- Neuropeptide Y has a protective role during murine retrovirus-induced neurological disease.Journal of virology · 2010Article
- Article
- Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root ganglia.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2009Article
- Innate immunity in the pathogenesis of polytropic retrovirus infection in the central nervous system.Immunologic research · 2009Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Toll-like receptor 7 (TLR7) recognizes guanidine-rich single-stranded (ss) viral RNA and is an important mediator of peripheral immune responses to several ssRNA viruses. However, the role that TLR7 plays in regulating the innate immune response to ssRNA virus infections in specific organs is not as clear. This is particularly true in the central nervous system (CNS) where microglia and astrocytes are often the first cells responding to virus infection instead of dendritic cells. In the current study, we examined the mechanism by which TLR7 contributes to ssRNA virus-induced neuroinflammation using a mouse model of polytropic retrovirus infection. The authors found that TLR7 was necessary for the early production of certain cytokines and chemokines, including CCL2 and tumor necrosis factor (TNF) and was also involved in the early activation of astrocytes. However, TLR7 was not necessary for cytokine production and astrocyte activation at later stages of infection and did not alter viral pathogenesis or viral replication in the brain. This suggests that other pathogen recognition receptors may be able to compensate for the lack of TLR7 during retrovirus infection in the CNS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.