ReviewSeminars in immunopathology2008
Central tolerance: what have we learned from mice?
Review in Seminars in immunopathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Semaphorins: from CD8⁺ T cells to cancer immunotherapy.Biomarker research · 2026Review
- Immune Checkpoint Inhibitor-Associated Cutaneous Adverse Events: Mechanisms of Occurrence.International journal of molecular sciences · 2024Review
- CD8 T cell tolerance results from eviction of immature autoreactive cells from the thymus.Science (New York, N.Y.) · 2023Article
- A Minimally Invasive, Accurate, and Efficient Technique for Intrathymic Injection in Mice.Journal of visualized experiments : JoVE · 2022Article
- Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis.The Journal of experimental medicine · 2022Article
- The thymus medulla and its control of αβT cell development.Seminars in immunopathology · 2021Review
- H60: A Unique Murine Hematopoietic Cell-Restricted Minor Histocompatibility Antigen for Graft-versus-Leukemia Effect.Frontiers in immunology · 2020Review
- T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33.The Journal of experimental medicine · 2019Article
- TCR Retrogenic Mice as a Model To Map Self-Tolerance Mechanisms to the Cancer Mucosa Antigen GUCY2C.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen.Nature communications · 2018Article
- mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice.Cell death and differentiation · 2014Article
- Elements of the B cell signalosome are differentially affected by mercury intoxication.Autoimmune diseases · 2014Article
- Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A mathematical model of immune activation with a unified self-nonself concept.Frontiers in immunology · 2013Article
- Examination of thymic positive and negative selection by flow cytometry.Journal of visualized experiments : JoVE · 2012Article
- A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self.Immunity · 2012Article
- T-cell tolerance: central and peripheral.Cold Spring Harbor perspectives in biology · 2012Article
- Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.Nature immunology · 2012Article
- Selection of self-reactive T cells in the thymus.Annual review of immunology · 2012Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Producing a healthy immune system capable of defending against pathogens, while avoiding autoimmunity, is dependent on thymic selection. Positive selection yields functional T cells that have the potential to recognize both self and foreign antigens. Therefore, negative selection exists to manage potentially self-reactive cells. Negative selection results from the induction of anergy, receptor editing, clonal diversion (agonist selection), and/or clonal deletion (apoptosis) in self-reactive clones. Clonal deletion has been inherently difficult to study because the cells of interest are undergoing apoptosis and being eliminated quickly. Furthermore, analysis of clonal deletion in humans has proved even more difficult due to availability of samples and lack of reagents. Mouse models have thus been instrumental in achieving our current understanding of central tolerance, and the evolution of elegant model systems has led to an explosion of new data to be assimilated. This review will focus on recent advances in the field of clonal deletion with respect to three aspects: the development of physiological model systems, signaling pathways that lead to apoptosis, and antigen presenting cell types involved in the induction of clonal deletion.
Indexed as
Identifiers
19015857What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.