ArticleOncogene2009
Stromal control of oncogenic traits expressed in response to the overexpression of GLI2, a pleiotropic oncogene.
Article in Oncogene, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- The Role of Keratin17 in Human Tumours.Frontiers in cell and developmental biology · 2022Review
- Diagnostic Value of Cytokeratin 17 during Oral Carcinogenesis: An Immunohistochemical Study.International journal of dentistry · 2021Article
- TFII-I-mediated polymerase pausing antagonizes GLI2 induction by TGFβ.Nucleic acids research · 2020Article
- Article
- SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer.Journal of experimental & clinical cancer research : CR · 2014Article
- GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis.Cell death & disease · 2014Article
- Regulation of DNA damage following termination of Hedgehog (HH) survival signaling at the level of the GLI genes in human colon cancer.Oncotarget · 2012Article
- Hedgehog signaling activation in the development of squamous cell carcinoma and adenocarcinoma of esophagus.International journal of biochemistry and molecular biology · 2012Article
- GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells.Cancer research · 2012Article
- Study of the differentially expressed genes in pleomorphic adenoma using cDNA microarrays.Pathology oncology research : POR · 2011Article
- Hedgehog signaling: networking to nurture a promalignant tumor microenvironment.Molecular cancer research : MCR · 2011Review
- Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells.Cancer research · 2011Article
- The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer.Oncotarget · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Hedgehog signaling is often activated in tumors, yet it remains unclear how GLI2, a transcription factor activated by this pathway, acts as an oncogene. We show that GLI2 is a pleiotropic oncogene. The overexpression induces genomic instability and blocks differentiation, likely mediated in part by enhanced expression of the stem cell gene SOX2. GLI2 also induces transforming growth factor (TGF)B1-dependent transdifferentiation of foreskin and tongue, but not gingival fibroblasts into myofibroblasts, creating an environment permissive for invasion by keratinocytes, which are in various stages of differentiation having downregulated GLI2. Thus, upregulated GLI2 expression is sufficient to induce a number of the acquired characteristics of tumor cells; however, the stroma, in a tissue-specific manner, determines whether certain GLI2 oncogenic traits are expressed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.