ArticleGenetics2009
The Caenorhabditis elegans ing-3 gene regulates ionizing radiation-induced germ-cell apoptosis in a p53-associated pathway.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation.Nucleic acids research · 2021Article
- Overexpression ofExperimental and therapeutic medicine · 2021Article
- ING Proteins: Tumour Suppressors or Oncoproteins.Cancers · 2021Review
- The Biological and Clinical Relevance of Inhibitor of Growth (ING) Genes in Non-Small Cell Lung Cancer.Cancers · 2019Review
- Parent-of-Origin-Dependent Gene Expression in Male and Female Schistosome Parasites.Genome biology and evolution · 2018Article
- INGs are potential drug targets for cancer.Journal of cancer research and clinical oncology · 2017Review
- SUMOylation of the ING1b tumor suppressor regulates gene transcription.Carcinogenesis · 2014Article
- The EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in C. elegans.Cell death and differentiation · 2011Article
- The p53 tumor suppressor is stabilized by inhibitor of growth 1 (ING1) by blocking polyubiquitination.PloS one · 2011Article
- Phylogeny and function of the invertebrate p53 superfamily.Cold Spring Harbor perspectives in biology · 2010Review
- Inhibitor of growth tumor suppressors in cancer progression.Cellular and molecular life sciences : CMLS · 2010Review
- Cancer models in Caenorhabditis elegans.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inhibitor of growth (ING) family of type II tumor suppressors are encoded by five genes in mammals and by three genes in Caenorhabditis elegans. All ING proteins contain a highly conserved plant homeodomain (PHD) zinc finger. ING proteins are activated by stresses, including ionizing radiation, leading to the activation of p53. ING proteins in mammals and yeast have recently been shown to read the histone code in a methylation-sensitive manner to regulate gene expression. Here we identify and characterize ing-3, the C. elegans gene with the highest sequence identity to the human ING3 gene. ING-3 colocalizes with chromatin in embryos, the germline, and somatic cells. The ing-3 gene is part of an operon but is also transcribed from its own promoter. Both ing-3(RNAi) and ing-3 mutant strains demonstrate that the gene likely functions in concert with the C. elegans p53 homolog, cep-1, to induce germ-cell apoptosis in response to ionizing radiation. Somatically, the ing-3 mutant has a weak kinker uncoordinated (kinker Unc) phenotype, indicating a possible neuronal function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.