ArticleProceedings of the National Academy of Sciences of the United States of America2008
Enhancement of sensitivity gain and frequency tuning by coupling of active hair bundles.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Efferent control of hair cells mechanically coupled by artificial membranes.Scientific reports · 2025Article
- The Critical Thing about the Ear's Sensory Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Frequency Shifts in a Local Oscillator Model for the Generation of Spontaneous Otoacoustic Emissions by the Lizard Ear.Audiology & neuro-otology · 2023Article
- Dynamics of Mechanically Coupled Hair-Cell Bundles of the Inner Ear.Biophysical journal · 2021Article
- Active Biomechanics of Sensory Hair Bundles.Cold Spring Harbor perspectives in medicine · 2019Review
- Reducing tectorial membrane viscoelasticity enhances spontaneous otoacoustic emissions and compromises the detection of low level sound.Scientific reports · 2019Article
- A Bundle of Mechanisms: Inner-Ear Hair-Cell Mechanotransduction.Trends in neurosciences · 2019Review
- Electrophysiological Measurements of Peripheral Vestibular Function-A Review of Electrovestibulography.Frontiers in systems neuroscience · 2017Review
- Salient features of otoacoustic emissions are common across tetrapod groups and suggest shared properties of generation mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- An active oscillator model describes the statistics of spontaneous otoacoustic emissions.Biophysical journal · 2014Article
- Enhanced signal-to-noise ratios in frog hearing can be achieved through amplitude death.Journal of the Royal Society, Interface · 2013Article
- Phantom tones and suppressive masking by active nonlinear oscillation of the hair-cell bundle.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- A mean-field approach to elastically coupled hair bundles.The European physical journal. E, Soft matter · 2012Article
- Striated organelle, a cytoskeletal structure positioned to modulate hair-cell transduction.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Coupling and elastic loading affect the active response by the inner ear hair cell bundles.PloS one · 2012Article
- Spontaneous voltage oscillations and response dynamics of a Hodgkin-Huxley type model of sensory hair cells.Journal of mathematical neuroscience · 2011Article
- Auditory mechanics of the tectorial membrane and the cochlear spiral.Current opinion in otolaryngology & head and neck surgery · 2011Review
- Somatic motility and hair bundle mechanics, are both necessary for cochlear amplification?Hearing research · 2011Article
- A critique of the critical cochlea: Hopf--a bifurcation--is better than none.Journal of neurophysiology · 2010Review
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The vertebrate inner ear possesses an active process that provides nonlinear amplification of mechanical stimuli. A candidate for this process is active hair bundle mechanics observed, for instance, for hair cells of the bullfrog's sacculus. Hair bundles in various inner ear organs are coupled by overlying membranes. Using a stochastic description of active hair bundle dynamics, we study the consequences of an elastic coupling on the properties of amplification. We report that collective effects in arrays of hair bundles can enhance the amplification gain and the sharpness of frequency tuning as compared with the performance of an isolated hair bundle. We also discuss the transient response elicited by the sudden onset of a periodic stimulus and its relation to temporal integration curves. Simulations of systems with a gradient of intrinsic frequencies show an enhanced amplification gain while preserving a frequency gradient, provided the coupling strength is similar to the hair bundle stiffness. We relate our findings to the situation in the bullfrog's sacculus and the mammalian cochlea.
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