Evidence map›Paper›PMID 19015388›Full record

ReviewMolecular interventions2008

Inside information: the unique features of visceral sensation.

David R Robinson, G F Gebhart

Open access · greenAbstract readReview
In one paragraph

Review in Molecular interventions, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 158 citations in OpenAlex.

  1. Trial
  2. Article
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  5. Article
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  8. Review
  9. Mechanisms of Transmission and Processing of Pain: A Narrative Review.International journal of environmental research and public health · 2023
    Review
  10. Article
  11. Opioid-Induced Pronociceptive Signaling in the Gastrointestinal Tract Is Mediated by Delta-Opioid Receptor Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Properties and Differential Expression of HFrontiers in physiology · 2021
    Review
  20. Analgesic effects of Phα1β toxin: a review of mechanisms of action involving pain pathways.The journal of venomous animals and toxins including tropical diseases · 2021
    Review

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

David R RobinsonDepartment of Anesthesiology, Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
G F Gebhart
University of Pittsburgh · US

Funding

PRIMARY VISCERAL AFFERENTS IN PAINR01NS035790 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAVIS, BRIAN M · 1997 to 2014
$5.1M
MECHANISMS AND MODULATION OF VISCERAL PAINR01NS019912 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GEBHART, GERALD F · 1985 to 2009
$3.7M
NINDS NIH HHS R01 NS019912NINDS NIH HHS R01 NS035790
6 · The paper itself

Abstract

Most of what is written and believed about pain and nociceptors originates from studies of the "somatic" (non-visceral) sensory system. As a result, the unique features of visceral pain are often overlooked. In the clinic, the management of visceral pain is typically poor, and drugs that are used with some efficacy to treat somatic pain often present unwanted effects on the viscera. For these reasons, a better understanding of visceral sensory neurons-particularly visceral nociceptors-is required. This review provides evidence of functional, morphological, and biochemical differences between visceral and non-visceral afferents, with a focus on potential nociceptive roles, and also considers some of the potential mechanisms of visceral mechanosensation.

Indexed as

VisceraCalcitonin Gene-Related PeptideHumansNociceptorsPainPlant LectinsSensationStress, MechanicalTRPV Cation ChannelsVisceral AfferentsCalcitonin Gene-Related PeptideGriffonia simplicifolia lectinsPlant LectinsTRPV1 receptorTRPV Cation Channels

Identifiers

PMID19015388
PMCPMC2732716
OpenAlexW1989609722

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.