ArticleAntimicrobial agents and chemotherapy2009
Variation in Salmonella enterica serovar typhi IncHI1 plasmids during the global spread of resistant typhoid fever.
Article in Antimicrobial agents and chemotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53 citing papers in PubMed.
- Temporal fluctuation of multidrug resistant salmonella typhi haplotypes in the mekong river delta region of Vietnam.PLoS neglected tropical diseases · 2011Trial
- PlasAnn: a curated plasmid-specific database and annotation pipeline for standardized gene and function analysis.Nucleic acids research · 2026Article
- Challenges and considerations for whole-genome-based antimicrobial resistance plasmid investigations.Antimicrobial agents and chemotherapy · 2025Review
- Determining genotype and antimicrobial resistance of Salmonella Typhi in environmental samples by amplicon sequencing.PLoS neglected tropical diseases · 2025Article
- Facile Synthesis ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Predominance of multidrug-resistant Salmonella Typhi genotype 4.3.1 with low-level ciprofloxacin resistance in Zanzibar.PLoS neglected tropical diseases · 2024Article
- Genotypic Diversity amongInternational journal of clinical microbiology · 2024Article
- An exploration of unusual antimicrobial resistance phenotypes in Salmonella Typhi from Blantyre, Malawi reveals the ongoing role of IncHI1 plasmids.Gates open research · 2024Article
- Identification of plasmids in avian-associated Escherichia coli using nanopore and illumina sequencing.BMC genomics · 2023Article
- Lociq provides a loci-seeking approach for enhanced plasmid subtyping and structural characterization.Communications biology · 2023Article
- Plasmid Composition, Antimicrobial Resistance and Virulence Genes Profiles of Ciprofloxacin- and Third-Generation Cephalosporin-Resistant FoodborneMicroorganisms · 2023Article
- IncHI1 plasmids mediated theFrontiers in microbiology · 2023Article
- Review
- Article
- Salmonella Typhi acquires diverse plasmids from other Enterobacteriaceae to develop cephalosporin resistance.Genomics · 2021Article
- Swine growth promotion with antibiotics or alternatives can increase antibiotic resistance gene mobility potential.Scientific reports · 2021Article
- A whole-genome screen identifies Salmonella enterica serovar Typhi genes involved in fluoroquinolone susceptibility.The Journal of antimicrobial chemotherapy · 2020Article
- Comparison of Commensal and Clinical Isolates for Diversity of Plasmids in Escherichia coli and Klebsiella pneumoniae.Antimicrobial agents and chemotherapy · 2020Article
- Population structure and antimicrobial resistance patterns of Salmonella Typhi isolates in urban Dhaka, Bangladesh from 2004 to 2016.PLoS neglected tropical diseases · 2020Article
- Transferable Plasmids ofFrontiers in microbiology · 2020Review
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Abstract
A global collection of plasmids of the IncHI1 incompatibility group from Salmonella enterica serovar Typhi were analyzed by using a combination of DNA sequencing, DNA sequence analysis, PCR, and microarrays. The IncHI1 resistance plasmids of serovar Typhi display a backbone of conserved gene content and arrangement, within which are embedded preferred acquisition sites for horizontal DNA transfer events. The variable regions appear to be preferred acquisition sites for DNA, most likely through composite transposition, which is presumably driven by the acquisition of resistance genes. Plasmid multilocus sequence typing, a molecular typing method for IncHI1 plasmids, was developed using variation in six conserved loci to trace the spread of these plasmids and to elucidate their evolutionary relationships. The application of this method to a collection of 36 IncHI1 plasmids revealed a chronological clustering of plasmids despite their difference in geographical origins. Our findings suggest that the predominant plasmid types present after 1993 have not evolved directly from the earlier predominant plasmid type but have displaced them. We propose that antibiotic selection acts to maintain resistance genes on the plasmid, but there is also competition between plasmids encoding the same resistance phenotype.
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