ArticleInfection and immunity2009
Interleukin-15 and NK1.1+ cells provide innate protection against acute Salmonella enterica serovar Typhimurium infection in the gut and in systemic tissues.
Article in Infection and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Inactivation of interleukin-15 reduces spontaneous atherosclerosis inFrontiers in physiology · 2026Article
- The unique role of innate lymphoid cells in cancer and the hepatic microenvironment.Cellular & molecular immunology · 2022Review
- Effect of the Microbiome on Intestinal Innate Immune Development in Early Life and the Potential Strategy of Early Intervention.Frontiers in immunology · 2022Review
- IL-15Rα-Independent IL-15 Signaling in Non-NK Cell-Derived IFNγ Driven Control ofFrontiers in immunology · 2021Article
- Enteric bacteria induce IFNγ and Granzyme B from human colonic Group 1 Innate Lymphoid Cells.Gut microbes · 2020Article
- The role of natural killer cells in Parkinson's disease.Experimental & molecular medicine · 2020Review
- Tracking of an OralFrontiers in immunology · 2020Article
- NKR-P1B expression in gut-associated innate lymphoid cells is required for the control of gastrointestinal tract infections.Cellular & molecular immunology · 2019Article
- Reversal of New Onset Type 1 Diabetes by OralFrontiers in immunology · 2019Article
- Human Gut-Associated Natural Killer Cells in Health and Disease.Frontiers in immunology · 2019Review
- Article
- IRF-1 promotes liver transplant ischemia/reperfusion injury via hepatocyte IL-15/IL-15Rα production.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- NK cells in mucosal defense against infection.BioMed research international · 2014Review
- Contribution of Thy1+ NK cells to protective IFN-γ production during Salmonella typhimurium infections.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Natural killer cells in asthma.Frontiers in immunology · 2013Article
- Natural killer (NK) cells in antibacterial innate immunity: angels or devils?Molecular medicine (Cambridge, Mass.) · 2012Review
- The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use.Microbes and infection · 2012Review
- The role of innate immunity in the host defense against intestinal bacterial pathogens.Current infectious disease reports · 2012Article
- Antibacterial role for natural killer cells in host defense to Bacillus anthracis.Infection and immunity · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Control of bacterial colonization at mucosal surfaces depends on rapid activation of the innate immune system. Interleukin-15 (IL-15) directs the development, maturation, and function of a population of cells positive for NK1.1, such as natural killer (NK) cells, which are critical components of the innate immune defense against several viral and bacterial pathogens. Using IL-15-deficient mice, in vivo depletion of NK1.1(+) cells from wild-type mice, and in vivo overexpression of IL-15 from a recombinant adenovirus, we tested the role of IL-15 and NK1.1(+) cells in innate protection of the murine gut and reticuloendothelial system from Salmonella enterica serovar Typhimurium infection. IL-15 and the NK1.1(+) cell population provided innate protection from serovar Typhimurium in mice at the enteric mucosae and in the reticuloendothelial system during murine typhoid. Interestingly, serovar Typhimurium extensively colonized the gut of IL-15(-/-) mice and wild-type C57BL/6 mice depleted of NK1.1(+) cells prior to infection, even though the animals were not pretreated with antibiotics to reduce colonization resistance and there was an absence of overt inflammation in the colon and cecum. Enhanced dissemination of Salmonella from the gut of mice depleted of NK1.1(+) cells correlated with a localized disruption of IL-17 in the colon. These data suggest a relationship between the gut ecosystem and the innate mucosal immune system, which may be linked via IL-15 and NK1.1(+) cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.