ArticleThe Journal of physiology2009
Cerebral non-oxidative carbohydrate consumption in humans driven by adrenaline.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Plasma pH does not influence the cerebral metabolic ratio during maximal whole body exercise.The Journal of physiology · 2011Trial
- The Impact of Inotropes and Vasopressors on Cerebral Oxygenation in Patients with Traumatic Brain Injury and Subarachnoid Hemorrhage: A Narrative Review.Brain sciences · 2024Review
- ALDH2 rs671 variant allele is associated with higher energy intake in middle-aged and elderly Japanese who routinely consume alcohol.Environmental health and preventive medicine · 2023Article
- Effect of adrenaline on serum mid-regional pro-atrial natriuretic peptide and central blood volume.Experimental physiology · 2022Article
- Trans-cerebral HCOJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Cerebral oxidative metabolism is decreased with extreme apnoea in humans; impact of hypercapnia.The Journal of physiology · 2016Article
- Influence of high altitude on cerebral blood flow and fuel utilization during exercise and recovery.The Journal of physiology · 2014Article
- Cerebral perfusion, oxygenation and metabolism during exercise in young and elderly individuals.The Journal of physiology · 2013Article
- Natural selection of mitochondria during somatic lifetime promotes healthy aging.Frontiers in neuroenergetics · 2013Article
- β2-adrenergic receptor and astrocyte glucose metabolism.Journal of molecular neuroscience : MN · 2012Article
- Reduced muscle activation during exercise related to brain oxygenation and metabolism in humans.The Journal of physiology · 2010Article
- Autonomic control of heart rate by metabolically sensitive skeletal muscle afferents in humans.The Journal of physiology · 2010Article
- Non-oxidative cerebral carbohydrate metabolism.The Journal of physiology · 2009Article
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During brain activation, the decrease in the ratio between cerebral oxygen and carbohydrate uptake (6 O(2)/(glucose + (1)/(2) lactate); the oxygen-carbohydrate index, OCI) is attenuated by the non-selective beta-adrenergic receptor antagonist propranolol, whereas OCI remains unaffected by the beta(1)-adrenergic receptor antagonist metroprolol. These observations suggest involvement of a beta(2)-adrenergic mechanism in non-oxidative metabolism for the brain. Therefore, we evaluated the effect of adrenaline (0.08 microg kg(-1) min(-1) i.v. for 15 min) and noradrenaline (0.5, 0.1 and 0.15 microg kg(-1) min(-1) i.v. for 20 min) on the arterial to internal jugular venous concentration differences (a-v diff) of O(2), glucose and lactate in healthy humans. Adrenaline (n = 10) increased the arterial concentrations of O(2), glucose and lactate (P < 0.05) and also increased the a-v diff for glucose from 0.6 +/- 0.1 to 0.8 +/- 0.2 mM (mean +/- s.d.; P < 0.05). The a-v diff for lactate shifted from a net cerebral release to an uptake and OCI was lowered from 5.1 +/- 1.5 to 3.6 +/- 0.4 (P < 0.05) indicating an 8-fold increase in the rate of non-oxidative carbohydrate uptake during adrenaline infusion (P < 0.01). Conversely, noradrenaline (n = 8) did not affect the OCI despite an increase in the a-v diff for glucose (P < 0.05). These results support that non-oxidative carbohydrate consumption for the brain is driven by a beta(2)-adrenergic mechanism, giving neurons an abundant provision of energy when plasma adrenaline increases.
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