Evidence map›Paper›PMID 19015193›Full record

Trial reportThe Journal of physiology2009

Opioid-mediated muscle afferents inhibit central motor drive and limit peripheral muscle fatigue development in humans.

Markus Amann, Lester T Proctor, Joshua J Sebranek, David F Pegelow, Jerome A Dempsey

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05619887 (Effect of Muscle Reflex Inhibition on Cardiorespiratory Responses to Exercise in Hypoxia), which is not on this map. Cited by 178 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
178citing papers in PubMed, 1 pooled it
13.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05619887 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of Muscle Reflex Inhibition on Cardiorespiratory Responses to Exercise in Hypoxia

TypeinterventionalSponsorUniversity of British ColumbiaRan2023 to 2024Enrolled14ConditionsDyspnea, Muscle StrainArmsFentanyl, Saline
3 · Its place in the literature

Who cites it

178 citing papers in PubMed, 1 synthesis or guideline pooled it, 374 citations in OpenAlex.

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  5. Effects of surgical and FFP2/N95 face masks on cardiopulmonary exercise capacity.Clinical research in cardiology : official journal of the German Cardiac Society · 2020
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118 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Markus AmannInstitute of Physiology, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland. markus.amann@physiol.biol.ethz.ch
Lester T Proctor
Joshua J Sebranek
David F Pegelow
Jerome A Dempsey
University of Wisconsin–Madison · USUniversity of Zurich · CH

Funding

HUMAN VENTILATORY ADAPTIONR01HL015469 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI DEMPSEY, JEROME A · 1985 to 2011
$3.7M
HUMAN VENTILLATORY ADAPTATIONR37HL015469 · NHLBI · UNIVERSITY OF WISCONSIN MADISON · PI DEMPSEY, JEROME A · 1988 to 1996
–
NHLBI NIH HHS HL-15469NHLBI NIH HHS R01 HL015469
6 · The paper itself

Abstract

We investigated the role of somatosensory feedback from locomotor muscles on central motor drive (CMD) and the development of peripheral fatigue during high-intensity endurance exercise. In a double-blind, placebo-controlled design, eight cyclists randomly performed three 5 km time trials: control, interspinous ligament injection of saline (5K(Plac), L3-L4) or intrathecal fentanyl (5K(Fent), L3-L4) to impair cortical projection of opioid-mediated muscle afferents. Peripheral quadriceps fatigue was assessed via changes in force output pre- versus postexercise in response to supramaximal magnetic femoral nerve stimulation (DeltaQ(tw)). The CMD during the time trials was estimated via quadriceps electromyogram (iEMG). Fentanyl had no effect on quadriceps strength. Impairment of neural feedback from the locomotor muscles increased iEMG during the first 2.5 km of 5K(Fent) versus 5K(Plac) by 12 +/- 3% (P < 0.05); during the second 2.5 km, iEMG was similar between trials. Power output was also 6 +/- 2% higher during the first and 11 +/- 2% lower during the second 2.5 km of 5K(Fent) versus 5K(Plac) (both P < 0.05). Capillary blood lactate was higher (16.3 +/- 0.5 versus 12.6 +/- 1.0%) and arterial haemoglobin O(2) saturation was lower (89 +/- 1 versus 94 +/- 1%) during 5K(Fent) versus 5K(Plac). Exercise-induced DeltaQ(tw) was greater following 5K(Fent) versus 5K(Plac) (-46 +/- 2 versus -33 +/- 2%, P < 0.001). Our results emphasize the critical role of somatosensory feedback from working muscles on the centrally mediated determination of CMD. Attenuated afferent feedback from exercising locomotor muscles results in an overshoot in CMD and power output normally chosen by the athlete, thereby causing a greater rate of accumulation of muscle metabolites and excessive development of peripheral muscle fatigue.

Indexed as

AdultAfferent PathwaysAnalgesics, OpioidDouble-Blind MethodElectromyographyFeedback, PhysiologicalFemoral NerveFentanylHumansMagneticsMaleMotor CortexMuscle FatigueMuscle, SkeletalPhysical EnduranceYoung AdultAnalgesics, OpioidFentanyl

Identifiers

PMID19015193
PMCPMC2670040
OpenAlexW1501427097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.