ArticleNucleic acids research2009
AS-ALPS: a database for analyzing the effects of alternative splicing on protein structure, interaction and network in human and mouse.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- APPRIS: selecting functionally important isoforms.Nucleic acids research · 2022Article
- Isoform Age - Splice Isoform Profiling Using Long-Read Technologies.Frontiers in molecular biosciences · 2021Review
- Exploring the functional impact of alternative splicing on human protein isoforms using available annotation sources.Briefings in bioinformatics · 2019Review
- APPRIS 2017: principal isoforms for multiple gene sets.Nucleic acids research · 2018Article
- An atlas of alternative splicing profiles and functional associations reveals new regulatory programs and genes that simultaneously express multiple major isoforms.Genome research · 2017Article
- MiasDB: A Database of Molecular Interactions Associated with Alternative Splicing of Human Pre-mRNAs.PloS one · 2016Article
- Network analysis reveals stage-specific changes in zebrafish embryo development using time course whole transcriptome profiling and prior biological knowledge.BioData mining · 2015Article
- Function of alternative splicing.Gene · 2013Review
- DBATE: database of alternative transcripts expression.Database : the journal of biological databases and curation · 2013Article
- APPRIS: annotation of principal and alternative splice isoforms.Nucleic acids research · 2013Article
- AS-EAST: a functional annotation tool for putative proteins encoded by alternatively spliced transcripts.Bioinformatics (Oxford, England) · 2012Article
- Evolutionary dynamics of human autoimmune disease genes and malfunctioned immunological genes.BMC evolutionary biology · 2012Article
- MAISTAS: a tool for automatic structural evaluation of alternative splicing products.Bioinformatics (Oxford, England) · 2011Article
- Verification of alternative splicing variants based on domain integrity, truncation length and intrinsic protein disorder.Nucleic acids research · 2011Article
- Splicing factor and exon profiling across human tissues.Nucleic acids research · 2010Article
- Divergence of exonic splicing elements after gene duplication and the impact on gene structures.Genome biology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have constructed a database, AS-ALPS (alternative splicing-induced alteration of protein structure), which provides information that would be useful for analyzing the effects of alternative splicing (AS) on protein structure, interactions with other bio-molecules and protein interaction networks in human and mouse. Several AS events have been revealed to contribute to the diversification of protein structure, which results in diversification of interaction partners or affinities, which in turn contributes to regulation of bio-molecular networks. Most AS variants, however, are only known at the sequence level. It is important to determine the effects of AS on protein structure and interaction, and to provide candidates for experimental targets that are relevant to network regulation by AS. For this purpose, the three-dimensional (3D) structures of proteins are valuable sources of information; however, these have not been fully exploited in any other AS-related databases. AS-ALPS is the only AS-related database that describes the spatial relationships between protein regions altered by AS ('AS regions') and both the proteins' hydrophobic cores and sites of inter-molecular interactions. This information makes it possible to infer whether protein structural stability and/or protein interaction are affected by each AS event. AS-ALPS can be freely accessed at http://as-alps.nagahama-i-bio.ac.jp and http://genomenetwork.nig.ac.jp/as-alps/.
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