ArticleThe Journal of allergy and clinical immunology2008
Differences in allergic sensitization by self-reported race and genetic ancestry.
Article in The Journal of allergy and clinical immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.The Journal of allergy and clinical immunology · 2013Pooled it
- A meta-analysis of Th2 pathway genetic variants and risk for allergic rhinitis.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2011Pooled it
- Asthma medication adherence: the role of God and other health locus of control factors.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2013Trial
- Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program.The Journal of allergy and clinical immunology · 2010Trial
- Dual-specificity phosphatase 1 as a pharmacogenetic modifier of inhaled steroid response among asthmatic patients.The Journal of allergy and clinical immunology · 2010Trial
- Associations between genetic ancestry and allergic outcomes at 10 years among Black children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Primate retroelement exonization and sexually dimorphicScience immunology · 2025Article
- Barriers to Timely Diagnosis of Eosinophilic Gastrointestinal Diseases.The journal of allergy and clinical immunology. In practice · 2024Article
- Fungal Aeroallergen Sensitization Patterns among Airway-Allergic Patients in Zagazig, Egypt.Journal of fungi (Basel, Switzerland) · 2023Article
- Article
- Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children.The Journal of allergy and clinical immunology · 2021Article
- Lower Use of Biologics for the Treatment of Asthma in Publicly Insured Individuals.The journal of allergy and clinical immunology. In practice · 2021Article
- Children with atopic eczema experiencing increased disease severity in the pollen season more often have hay fever at a young age and a dark skin type.The Journal of dermatology · 2021Article
- Effectiveness of beta blockers in patients with and without a history of myocardial infarction.European journal of clinical pharmacology · 2020Article
- Parental and child factors associated with inhalant and food allergy in a population-based prospective cohort study: the Generation R Study.European journal of pediatrics · 2019Article
- Cockroach allergen component analysis of children with or without asthma and rhinitis in an inner-city birth cohort.The Journal of allergy and clinical immunology · 2019Observational
- Acute Severe Asthma in Adolescent and Adult Patients: Current Perspectives on Assessment and Management.Journal of clinical medicine · 2019Review
- How does race and ethnicity effect the precision treatment of asthma?Expert review of precision medicine and drug development · 2019Article
- Seasonal Allergies and Psychiatric Disorders in the United States.International journal of environmental research and public health · 2018Article
- Allergic sensitization and objective measures of sleep in urban school-aged children with asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2017Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMany allergic conditions occur more frequently in African American patients when compared with white patients; however, it is not known whether this represents genetic predisposition or disparate environmental exposures.
objectiveWe sought to assess the relationship of self-reported race and genetic ancestry to allergic sensitization.
methodsWe included 601 women enrolled in a population-based cohort study whose self-reported race was African American or white. Genetic ancestry was estimated by using markers that differentiate West African and European ancestry. We assessed the relationship between allergic sensitization (defined as > or =1 allergen-specific IgE results) and both self-reported race and genetic ancestry. Regression models adjusted for sociodemographic variables, environmental exposures, and location of residence.
resultsThe average proportion of West African ancestry in African American participants was 0.69, whereas the mean proportion of European ancestry in white participants was 0.79. Self-reported African American race was associated with allergic sensitization when compared with those who reported being white (adjusted odds ratio, 2.19; 95% CI, 1.22-3.93), even after adjusting for other variables. Genetic ancestry was not significantly associated with allergic sensitization after accounting for location of residence (adjusted odds ratio, 2.09 for urban vs suburban residence; 95% CI, 1.32-3.31).
conclusionSelf-reported race and location of residence appeared to be more important predictors of allergic sensitization when compared with genetic ancestry, suggesting that the disparity in allergic sensitization by race might be primarily a result of environmental factors rather than genetic differences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.