ArticleBMC infectious diseases2008
Effect of treating Schistosoma haematobium infection on Plasmodium falciparum-specific antibody responses.
Article in BMC infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Comparative Assessment of Health Benefits of Praziquantel Treatment of Urogenital Schistosomiasis in Preschool and Primary School-Aged Children.BioMed research international · 2016Trial
- Stage specific immune responses to schistosomes may explain conflicting results in malaria-schistosome coinfection studies.Infectious Disease Modelling · 2025Article
- Malaria, Urogenital Schistosomiasis, and Anaemia in Pregnant Ghanaian Women.Journal of parasitology research · 2023Article
- Humoral antimalaria immune response in Nigerian children exposed to helminth and malaria parasites.Frontiers in immunology · 2022Article
- Effect of hookworm infection and anthelmintic treatment on naturally acquired antibody responses against the GMZ2 malaria vaccine candidate and constituent antigens.BMC infectious diseases · 2021Article
- Cytokine profiles ofCytokine: X · 2019Article
- Malaria endemicity and co-infection with tissue-dwelling parasites in Sub-Saharan Africa: a review.Infectious diseases of poverty · 2015Review
- Identifying and evaluating field indicators of urogenital schistosomiasis-related morbidity in preschool-aged children.PLoS neglected tropical diseases · 2015Article
- Group 2 innate lymphoid cell proportions are diminished in young helminth infected children and restored by curative anti-helminthic treatment.PLoS neglected tropical diseases · 2015Article
- Coinfection with Plasmodium falciparum and Schistosoma haematobium: additional evidence of the protective effect of Schistosomiasis on malaria in Senegalese children.The American journal of tropical medicine and hygiene · 2014Article
- Immunological consequences of antihelminthic treatment in preschool children exposed to urogenital schistosome infection.Journal of tropical medicine · 2013Article
- Schistosoma mansoni infection impairs antimalaria treatment and immune responses of rhesus macaques infected with mosquito-borne Plasmodium coatneyi.Infection and immunity · 2012Article
- Atopy is inversely related to schistosome infection intensity: a comparative study in Zimbabwean villages with distinct levels of Schistosoma haematobium infection.International archives of allergy and immunology · 2012Article
- Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium.Scientific reports · 2012Article
- Exposure, infection, systemic cytokine levels and antibody responses in young children concurrently exposed to schistosomiasis and malaria.Parasitology · 2011Article
- Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4.Parasite immunology · 2011Article
- Article
- Patent filarial infection modulates malaria-specific type 1 cytokine responses in an IL-10-dependent manner in a filaria/malaria-coinfected population.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Circulating cytokine levels and antibody responses to human Schistosoma haematobium: IL-5 and IL-10 levels depend upon age and infection status.Parasite immunologyArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundThe overlapping geographical and socio-economic distribution of malaria and helminth infection has led to several studies investigating the immunological and pathological interactions of these parasites. This study focuses on the effect of treating schistosome infections on natural human immune responses directed against plasmodia merozoite surface proteins MSP-1 (DPKMWR, MSP1(19)), and MSP-2 (CH150 and Dd2) which are potential vaccine candidates as well as crude malaria (schizont) and schistosome (whole worm homogenate) proteins.
methodsIgG1 and IgG3 antibody responses directed against Schistosoma haematobium crude adult worm antigen (WWH) and Plasmodium falciparum antigens (merozoite surface proteins 1/2 and schizont extract), were measured by enzyme linked immunosorbent assay (ELISA) in 117 Zimbabweans (6-18 years old) exposed to S. haematobium and P. falciparum infection. These responses were measured before and after anti-helminth treatment with praziquantel to determine the effects of treatment on anti-plasmodial/schistosome responses.
resultsThere were no significant associations between antibody responses (IgG1/IgG3) directed against P. falciparum and schistosomes before treatment. Six weeks after schistosome treatment there were significant changes in levels of IgG1 directed against schistosome crude antigens, plasmodia crude antigens, MSP-1(19), MSP-2 (Dd2), and in IgG3 directed against MSP-1(19). However, only changes in anti-schistosome IgG1 were attributable to the anti-helminth treatment.
conclusionThere was no association between anti-P. falciparum and S. haematobium antibody responses in this population and anti-helminth treatment affected only anti-schistosome responses and not responses against plasmodia crude antigens or MSP-1 and -2 vaccine candidates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.