ArticleBMC genomics2008
Genomic characterization of putative allergen genes in peach/almond and their synteny with apple.
Article in BMC genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 68 citations in OpenAlex.
- Pru du 1, the BetClinical and translational allergy · 2022Article
- Structure and Zeatin Binding of the Peach AllergenJournal of agricultural and food chemistry · 2021Article
- An Updated Overview of Almond Allergens.Nutrients · 2021Review
- Peach allergen Pru p 1 content is generally low in fruit but with large variation in different varieties.Clinical and translational allergy · 2021Article
- Immunoglobulin E-Binding Pattern of Canadian Peanut Allergic Children and Cross-Reactivity with Almond, Hazelnut and Pistachio.Biomolecules · 2020Article
- Review
- Cross-React: a new structural bioinformatics method for predicting allergen cross-reactivity.Bioinformatics (Oxford, England) · 2017Article
- A qRT-PCR assay for the expression of all Mal d 1 isoallergen genes.BMC plant biology · 2013Article
- Molecular characterization of peach PR genes and their induction kinetics in response to bacterial infection and signaling molecules.Plant cell reports · 2012Article
- Genomic organisation of the Mal d 1 gene cluster on linkage group 16 in apple.Molecular breeding : new strategies in plant improvement · 2012Article
- The Y-segment of novel cold dehydrin genes is conserved and codons in the PR-10 genes are under positive selection in Oxytropis (Fabaceae) from contrasting climates.Molecular genetics and genomics : MGG · 2012Article
- Characterisation of the Vitis vinifera PR10 multigene family.BMC plant biology · 2010Article
- Mapping SNP-anchored genes using high-resolution melting analysis in almond.Molecular genetics and genomics : MGG · 2009Article
- The RNA hydrolysis and the cytokinin binding activities of PR-10 proteins are differently performed by two isoforms of the Pru p 1 peach major allergen and are possibly functionally related.Plant physiology · 2009Article
- Functional genomics of allergen gene families in fruits.Nutrients · 2009Review
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFruits from several species of the Rosaceae family are reported to cause allergic reactions in certain populations. The allergens identified belong to mainly four protein families: pathogenesis related 10 proteins, thaumatin-like proteins, lipid transfer proteins and profilins. These families of putative allergen genes in apple (Mal d 1 to 4) have been mapped on linkage maps and subsequent genetic study on allelic diversity and hypoallergenic traits has been carried out recently. In peach (Prunus persica), these allergen gene families are denoted as Pru p 1 to 4 and for almond (Prunus dulcis)Pru du 1 to 4. Genetic analysis using current molecular tools may be helpful to establish the cause of allergenicity differences observed among different peach cultivars. This study was to characterize putative peach allergen genes for their genomic sequences and linkage map positions, and to compare them with previously characterized homologous genes in apple (Malus domestica).
resultsEight Pru p/du 1 genes were identified, four of which were new. All the Pru p/du 1 genes were mapped in a single bin on the top of linkage group 1 (G1). Five Pru p/du 2 genes were mapped on four different linkage groups, two very similar Pru p/du 2.01 genes (A and B) were on G3, Pru p/du 2.02 on G7,Pru p/du 2.03 on G8 and Pru p/du 2.04 on G1. There were differences in the intron and exon structure in these Pru p/du 2 genes and in their amino acid composition. Three Pru p/du 3 genes (3.01-3.03) containing an intron and a mini exon of 10 nt were mapped in a cluster on G6. Two Pru p/du 4 genes (Pru p/du 4.01 and 4.02) were located on G1 and G7, respectively. The Pru p/du 1 cluster on G1 aligned to the Mal d 1 clusters on LG16; Pru p/du 2.01A and B on G3 to Mal d 2.01A and B on LG9; the Pru p/du 3 cluster on G6 to Mal d 3.01 on LG12; Pru p/du 4.01 on G1 to Mal d 4.03 on LG2; and Pru p/du 4.02 on G7 to Mal d 4.02 on LG2.
conclusionA total of 18 putative peach/almond allergen genes have been mapped on five linkage groups. Their positions confirm the high macro-synteny between peach/almond and apple. The insight gained will help to identify key genes causing differences in allergenicity among different cultivars of peach and other Prunus species.
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